OBJECTIVE: To examine the relationship between birth weight and later low-grade inflammation in children and adolescents. STUDY DESIGN: We selected 166 children (49.4% boys; aged, 9.5 +/- 0.3 years) and 126 adolescents (43.7% males; aged, 15.5 +/- 0.4 years) from the Swedish part of the European Youth Heart Study. Birth weight data were collected from parental recall. Low-grade inflammatory markers include C-reactive protein, fibrinogen, and complement factors C3 and C4. Fatness was measured by the sum of 5 skinfold thicknesses. Cardiorespiratory fitness was measured with a maximal ergometer bike test. The association between birth weight and low-grade inflammatory markers was examined with multiple regression analyses. RESULTS: Birth weight was negatively associated with fibrinogen (beta = -0.059; P = .036), C3 (beta = -0.019; P = .010), and C4 (beta = -0.024; P = .031), after controlling for sex, pubertal status, mother's body mass index and socioeconomic status, fatness and fitness. Birth weight was not associated to later C-reactive protein level (all P > .1). CONCLUSIONS: Our results showed that smaller birth weight is associated with chronic low-grade inflammation in children and adolescents. Because of the implication of complement factors on atherosclerosis process, these results contribute to explain the increased cardiovascular risk associated with low birth weight.
OBJECTIVE: To examine the relationship between birth weight and later low-grade inflammation in children and adolescents. STUDY DESIGN: We selected 166 children (49.4% boys; aged, 9.5 +/- 0.3 years) and 126 adolescents (43.7% males; aged, 15.5 +/- 0.4 years) from the Swedish part of the European Youth Heart Study. Birth weight data were collected from parental recall. Low-grade inflammatory markers include C-reactive protein, fibrinogen, and complement factors C3 and C4. Fatness was measured by the sum of 5 skinfold thicknesses. Cardiorespiratory fitness was measured with a maximal ergometer bike test. The association between birth weight and low-grade inflammatory markers was examined with multiple regression analyses. RESULTS: Birth weight was negatively associated with fibrinogen (beta = -0.059; P = .036), C3 (beta = -0.019; P = .010), and C4 (beta = -0.024; P = .031), after controlling for sex, pubertal status, mother's body mass index and socioeconomic status, fatness and fitness. Birth weight was not associated to later C-reactive protein level (all P > .1). CONCLUSIONS: Our results showed that smaller birth weight is associated with chronic low-grade inflammation in children and adolescents. Because of the implication of complement factors on atherosclerosis process, these results contribute to explain the increased cardiovascular risk associated with low birth weight.
Authors: J M Goldstein; S Cherkerzian; S L Buka; G Fitzmaurice; M Hornig; M Gillman; S O'Toole; R P Sloan Journal: J Dev Orig Health Dis Date: 2011-12 Impact factor: 2.401
Authors: Francisco B Ortega; Jonatan R Ruiz; Anita Hurtig-Wennlöf; Aline Meirhaeghe; Marcela González-Gross; Luis A Moreno; Dénes Molnar; Anthony Kafatos; Frederic Gottrand; Kurt Widhalm; Idoia Labayen; Michael Sjöström Journal: Diabetes Date: 2011-07-13 Impact factor: 9.461
Authors: Francisco Jesus Llorente-Cantarero; Concepción M Aguilera; Juan Luis Perez-Navero; Angel Gil; Juan de Dios Benitez-Sillero; Mercedes Gil-Campos Journal: Front Nutr Date: 2022-04-21
Authors: Idoia Labayen; Jonatan R Ruiz; Francisco B Ortega; Helle-Mai Loit; Jaanus Harro; Toomas Veidebaum; Michael Sjöström Journal: Diabetes Care Date: 2010-01-07 Impact factor: 19.112