| Literature DB >> 19592246 |
Sarala Balachandran1, Atish Rodge, Pradip K Gadekar, Vitthal N Yadav, Divya Kamath, Anshu Chetrapal-Kunwar, Pooja Bhatt, Shaila Srinivasan, Somesh Sharma, Ram A Vishwakarma, Nilesh M Dagia.
Abstract
A series of novel 1,2,4-oxadiazole, phthalimide, amide and other derivatives of ISO-1 were synthesized and probed for inhibition of macrophage migration inhibitory factor (MIF) activity. Several compounds inhibited MIF enzymatic activity at levels better than ISO-1. Of note, compounds 7, 22, 23, 24, 25 and 27 inhibited the spontaneous secretion/release/recognition of MIF from freshly isolated human peripheral blood mononuclear cells and, more importantly, inhibited the MIF-induced production of interleukin-6 (IL-6) and/or interleukin-1beta (IL-1beta) significantly better than ISO-1.Entities:
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Year: 2009 PMID： 19592246 DOI： 10.1016/j.bmcl.2009.06.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823