Literature DB >> 19588535

Port wine stain progression: a potential consequence of delayed and inadequate treatment?

Kira Minkis1, Roy G Geronemus, Elizabeth K Hale.   

Abstract

BACKGROUND AND OBJECTIVES: Port wine stains are congenital low-flow vascular malformations of the skin. Unlike hemangiomas, PWS do not involute with time, but rather if left untreated can hypertrophy and develop nodularity. Laser therapy of PWS particularly with pulsed-dye lasers, is a safe, well-established treatment that is successful in the majority of patients, especially for younger patients. Patients that fail to receive treatment early in life may subsequent develop lesions more likely to progress. STUDY DESIGN/PATIENTS AND METHODS: A case report and review of the literature are presented. We report a 43 year-old man born with a port-wine stain on the right side of his face that extended in the V2 distribution on his face. He had undergone several sessions with a pulsed-dye laser, the sequential dual-wavelength (595 nm and 1064 nm) laser and a CO2 resurfacing laser from the age of 26 but failed to follow through with a sufficient number of treatments to prevent hypertrophy.
RESULTS: Due to an insufficient number and interval of treatments (with only 7 treatments over 16 years starting at age 26) with the various lasers, the patient's port wine stain continued to progress in color and development of nodularity.
CONCLUSIONS: Patients born with port wine stains should have early laser treatment to achieve optimal results. Delay in treatment, as in this patient until age 26, may result in hard to treat PWS that can continue to progress in nodularity. This case illustrates the hypertrophy and nodularity that can occur due to progression of a PWS with failure to follow through with sufficient number of laser treatments. Copyright 2009 Wiley-Liss, Inc.

Entities:  

Mesh:

Year:  2009        PMID: 19588535      PMCID: PMC4690461          DOI: 10.1002/lsm.20788

Source DB:  PubMed          Journal:  Lasers Surg Med        ISSN: 0196-8092            Impact factor:   4.025


  24 in total

Review 1.  Description and analysis of treatments for port-wine stain birthmarks.

Authors:  Kristen M Kelly; Bernard Choi; Samantha McFarlane; Alison Motosue; Byungjo Jung; Misbah H Khan; Julio C Ramirez-San-Juan; J Stuart Nelson
Journal:  Arch Facial Plast Surg       Date:  2005 Sep-Oct

2.  Squamous cell carcinoma arising within a facial port-wine stain treated by mohs micrographic surgical excision.

Authors:  Neil Rajan; Jeremy Ryan; James A A Langtry
Journal:  Dermatol Surg       Date:  2006-06       Impact factor: 3.398

Review 3.  The medical necessity of evaluation and treatment of port-wine stains.

Authors:  R G Geronemus; R Ashinoff
Journal:  J Dermatol Surg Oncol       Date:  1991-01

4.  Thermal relaxation of port-wine stain vessels probed in vivo: the need for 1-10-millisecond laser pulse treatment.

Authors:  C C Dierickx; J M Casparian; V Venugopalan; W A Farinelli; R R Anderson
Journal:  J Invest Dermatol       Date:  1995-11       Impact factor: 8.551

5.  Treatment of port-wine stains.

Authors:  A N Kauvar; R G Geronemus
Journal:  N Engl J Med       Date:  1998-08-27       Impact factor: 91.245

6.  The incidence of birthmarks in the neonate.

Authors:  A H Jacobs; R G Walton
Journal:  Pediatrics       Date:  1976-08       Impact factor: 7.124

7.  Port-wine stains. A disease of altered neural modulation of blood vessels?

Authors:  B R Smoller; S Rosen
Journal:  Arch Dermatol       Date:  1986-02

8.  Facial port-wine stains and Sturge-Weber syndrome.

Authors:  O Enjolras; M C Riche; J J Merland
Journal:  Pediatrics       Date:  1985-07       Impact factor: 7.124

9.  Port-wine stain nodules in the adult: report of 20 cases treated by CO2 laser vaporization.

Authors:  J del Pozo; E Fonseca
Journal:  Dermatol Surg       Date:  2001-08       Impact factor: 3.398

10.  Pilot study examining the combined use of pulsed dye laser and topical Imiquimod versus laser alone for treatment of port wine stain birthmarks.

Authors:  Cheng-Jen Chang; Yen-Chang Hsiao; Martin C Mihm; J Stuart Nelson
Journal:  Lasers Surg Med       Date:  2008-11       Impact factor: 4.025

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  12 in total

1.  Histological study on the treatment of vascular malformations resistant to pulsed dye laser.

Authors:  Tokuya Omi; Kawana Seiji; Shigeru Sato; Zenya Naito
Journal:  Laser Ther       Date:  2013

Review 2.  Laser and IPL treatment of port-wine stains: therapy options, limitations, and practical aspects.

Authors:  Annette Klein; Wolfgang Bäumler; Michael Landthaler; Philipp Babilas
Journal:  Lasers Med Sci       Date:  2011-03-10       Impact factor: 3.161

3.  Experimental study on the vascular thermal response to visible laser pulses.

Authors:  D Li; B Chen; W J Wu; G X Wang; Y L He; Z X Ying
Journal:  Lasers Med Sci       Date:  2014-07-22       Impact factor: 3.161

4.  The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities.

Authors:  Bernard Choi; Wenbin Tan; Wangcun Jia; Sean M White; Wesley J Moy; Bruce Y Yang; Jiang Zhu; Zhongping Chen; Kristen M Kelly; J Stuart Nelson
Journal:  IEEE J Sel Top Quantum Electron       Date:  2015-10-26       Impact factor: 4.544

5.  Pulsed Dye Laser Treatment of Port-Wine Stains in Infancy Without the Need for General Anesthesia.

Authors:  Hana Jeon; Leonard J Bernstein; Daniel A Belkin; Sabrina Ghalili; Roy G Geronemus
Journal:  JAMA Dermatol       Date:  2019-04-01       Impact factor: 10.282

6.  Quality of life in adults with facial port-wine stains.

Authors:  Solveig L Hagen; Katherine R Grey; Dorota Z Korta; Kristen M Kelly
Journal:  J Am Acad Dermatol       Date:  2016-12-09       Impact factor: 11.527

7.  Societal-Perceived Health Utility of Hypertrophic Facial Port-Wine Stain and Laser Treatment.

Authors:  Alyssa Heiser; Nate Jowett; Jessica Occhiogrosso; Oren Tessler; Oon T Tan
Journal:  Facial Plast Surg Aesthet Med       Date:  2020-04-22

Review 8.  The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.

Authors:  Vi Nguyen; Marcelo Hochman; Martin C Mihm; J Stuart Nelson; Wenbin Tan
Journal:  Int J Mol Sci       Date:  2019-05-07       Impact factor: 5.923

Review 9.  Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies.

Authors:  Ethan J Kilmister; Lauren Hansen; Paul F Davis; Sean R R Hall; Swee T Tan
Journal:  Front Surg       Date:  2021-02-09

Review 10.  Consensus Statement for the Management and Treatment of Port-Wine Birthmarks in Sturge-Weber Syndrome.

Authors:  Sara Sabeti; Karen L Ball; Craig Burkhart; Lawrence Eichenfield; Esteban Fernandez Faith; Ilona J Frieden; Roy Geronemus; Deepti Gupta; Andrew C Krakowski; Moise L Levy; Denise Metry; J Stuart Nelson; Megha M Tollefson; Kristen M Kelly
Journal:  JAMA Dermatol       Date:  2021-01-01       Impact factor: 10.282

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