OBJECTIVE: To assess the utility of the International HIV Dementia Scale (IHDS) and Centre for Epidemiological Studies Depression Scale (CESD) as rapid screening tools of depression and HIV dementia amongst patients with low cluster of differentiation 4 (CD4) counts. METHOD: The rapid screening tools were tested on a sample of 20 patients with low CD4 counts who were recruited from the inpatient ward at McCord Hospital from August to October 2007. RESULTS: The CESD was found to have 91 % sensitivity and 44 % specificity. Using the recommended cut-off of 10, the sensitivity of the IHDS was 88 %. The specificity was 50 %. The results suggest that CESD and IHDS are sensitive, however their low specificity may limit their clinical utility. CONCLUSIONS: This is a pilot study and no firm conclusions are drawn. Further research is needed to verify the high burden of depression and neuro-cognitive impairment (NCI) among people with low CD4. A larger study is needed to validate the IHDS in South Africa. Other researchers are encouraged to validate and determine the optimal cut off value for the IHDS in their local population.
OBJECTIVE: To assess the utility of the International HIV Dementia Scale (IHDS) and Centre for Epidemiological Studies Depression Scale (CESD) as rapid screening tools of depression and HIV dementia amongst patients with low cluster of differentiation 4 (CD4) counts. METHOD: The rapid screening tools were tested on a sample of 20 patients with low CD4 counts who were recruited from the inpatient ward at McCord Hospital from August to October 2007. RESULTS: The CESD was found to have 91 % sensitivity and 44 % specificity. Using the recommended cut-off of 10, the sensitivity of the IHDS was 88 %. The specificity was 50 %. The results suggest that CESD and IHDS are sensitive, however their low specificity may limit their clinical utility. CONCLUSIONS: This is a pilot study and no firm conclusions are drawn. Further research is needed to verify the high burden of depression and neuro-cognitive impairment (NCI) among people with low CD4. A larger study is needed to validate the IHDS in South Africa. Other researchers are encouraged to validate and determine the optimal cut off value for the IHDS in their local population.
Authors: Sérgio Monteiro de Almeida; Rujvi Kamat; Mariana Cherner; Anya Umlauf; Clea E Ribeiro; Ana Paula de Pereira; Donald Franklin; Robert K Heaton; Ronald J Ellis Journal: J Acquir Immune Defic Syndr Date: 2017-03-01 Impact factor: 3.731
Authors: Reuben N Robbins; Robert H Remien; Claude A Mellins; John A Joska; Dan J Stein Journal: AIDS Patient Care STDS Date: 2011-09-15 Impact factor: 5.078
Authors: Noeline Nakasujja; Richard L Skolasky; Seggane Musisi; Peter Allebeck; Kevin Robertson; Allan Ronald; Elly Katabira; David B Clifford; Ned Sacktor Journal: BMC Psychiatry Date: 2010-06-10 Impact factor: 3.630
Authors: Thep Chalermchai; Victor Valcour; Pasiri Sithinamsuwan; Suteeraporn Pinyakorn; David Clifford; Robert H Paul; Somporn Tipsuk; James L K Fletcher; Victor Degruttola; Silvia Ratto-Kim; Nicholas Hutchings; Cecilia Shikuma; Jintanat Ananworanich Journal: J Neurovirol Date: 2013-03-13 Impact factor: 2.643
Authors: Reuben N Robbins; John A Joska; Kevin G F Thomas; Dan J Stein; Teboho Linda; Claude A Mellins; Robert H Remien Journal: Clin Neuropsychol Date: 2013-01-21 Impact factor: 3.535