Literature DB >> 1958753

Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma.

W Fiedler1, H J Weh, W Zeller, C Fonatsch, J Hillion, C Larsen, B Wörmann, D K Hossfeld.   

Abstract

Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL 2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.

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Year:  1991        PMID： 1958753     DOI： 10.1007/bf01698379

Source DB:  PubMed          Journal:  Ann Hematol        ISSN： 0939-5555            Impact factor:   3.673


  25 in total

1.  Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).

Authors:  M Thangavelu; O Olopade; E Beckman; J W Vardiman; R A Larson; T W McKeithan; M M Le Beau; J D Rowley
Journal:  Genes Chromosomes Cancer       Date:  1990-07       Impact factor: 5.006

2.  Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

Authors:  G Nuñez; L London; D Hockenbery; M Alexander; J P McKearn; S J Korsmeyer
Journal:  J Immunol       Date:  1990-05-01       Impact factor: 5.422

3.  Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas.

Authors:  L M Weiss; R A Warnke; J Sklar; M L Cleary
Journal:  N Engl J Med       Date:  1987-11-05       Impact factor: 91.245

4.  Chromosome abnormalities in poorly differentiated lymphocytic lymphoma.

Authors:  S Fukuhara; J D Rowley; D Variakojis; H M Golomb
Journal:  Cancer Res       Date:  1979-08       Impact factor: 12.701

5.  Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations.

Authors:  G J Mufti; T J Hamblin; D G Oscier; S Johnson
Journal:  Blood       Date:  1983-11       Impact factor: 22.113

6.  18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance.

Authors:  K Offit; P R Koduru; R Hollis; D Filippa; S C Jhanwar; B C Clarkson; R S Chaganti
Journal:  Br J Haematol       Date:  1989-06       Impact factor: 6.998

7.  Pre-B-cell leukemia with a t(8; 14) and a t(14; 18) translocation is preceded by follicular lymphoma.

Authors:  C E Gauwerky; J Hoxie; P C Nowell; C M Croce
Journal:  Oncogene       Date:  1988-05       Impact factor: 9.867

8.  Correlation of chromosome abnormalities with histologic and immunologic characteristics in non-Hodgkin's lymphoma and adult T cell leukemia-lymphoma. Fifth International Workshop on Chromosomes in Leukemia-Lymphoma.

Authors: 
Journal:  Blood       Date:  1987-11       Impact factor: 22.113

9.  Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18).

Authors:  T J McDonnell; S J Korsmeyer
Journal:  Nature       Date:  1991-01-17       Impact factor: 49.962

10.  Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia.

Authors:  C E Gauwerky; K Huebner; M Isobe; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205
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  5 in total

1.  B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.

Authors:  Matija Snuderl; Olga K Kolman; Yi-Bin Chen; Jessie J Hsu; Adam M Ackerman; Paola Dal Cin; Judith A Ferry; Nancy Lee Harris; Robert P Hasserjian; Lawrence R Zukerberg; Jeremy S Abramson; Ephraim P Hochberg; Hang Lee; Alfred I Lee; Christiana E Toomey; Aliyah R Sohani
Journal:  Am J Surg Pathol       Date:  2010-03       Impact factor: 6.394

Review 2.  Molecular pathology of low grade malignant lymphomas.

Authors:  H Ratech
Journal:  Med Oncol       Date:  1995-09       Impact factor: 3.064

3.  Twenty-three cases of acute lymphoblastic leukemia with translocation t(4;11)(q21;q23): the implication of additional chromosomal aberrations.

Authors:  C Schoch; H Rieder; M Freund; D Hoelzer; H Riehm; C Fonatsch
Journal:  Ann Hematol       Date:  1995-04       Impact factor: 3.673

4.  Double- and triple-hit lymphomas can present with features suggestive of immaturity, including TdT expression, and create diagnostic challenges.

Authors:  Laura Moench; Zohar Sachs; Garth Aasen; Michelle Dolan; Vanessa Dayton; Elizabeth L Courville
Journal:  Leuk Lymphoma       Date:  2016-02-18

5.  De Novo Precursor B-Lymphoblastic Leukemia/Lymphoma With Double-Hit Gene Rearrangements (MYC/BCL-2) Presented With Spinal Cord Compression and Acquired Factor XIII Deficiency.

Authors:  Dina Sameh Soliman; Ahmad Al-Sabbagh; Feryal Ibrahim; Shehab Fareed; Mohamed Talaat; Mohamed A Yassin
Journal:  J Hematol (Brossard)       Date:  2017-07-20
  5 in total

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