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Literature DB >> 19586665

Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation.

Ana Pocivavsek¹, Irina Mikhailenko, Dudley K Strickland, G William Rebeck.

Abstract

Apolipoprotein E (apoE)-induced activation of low-density lipoprotein receptor (LDL) family members reduces inflammatory responses by suppressing c-Jun N-terminal kinase (JNK) activation. We aimed to identify which specific receptor family member mediates the effect of apoE on inflammation in primary cultures of microglia. Low-density lipoprotein receptor-related protein 1 (LRP1)-deficient (LRP1-/-) microglia were derived from mice using tissue-specific loxP/Cre recombination. Using a peptide formed from the receptor-binding region of apoE (EP), we found that LRP1 mediates the effects of apoE on microglial inflammation. Microglial LRP1 was also essential for EP to suppress JNK activation induced by lipopolysaccharide.

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Year: 2009 PMID： 19586665 PMCID： PMC2745483 DOI： 10.1016/j.jneuroim.2009.06.010

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

71 in total

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Journal: J Neurosci Date: 1998-03-01 Impact factor: 6.167

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Journal: J Neuroimmunol Date: 1997-06 Impact factor: 3.478

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Journal: Science Date: 1997-08-01 Impact factor: 47.728

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Journal: J Biol Chem Date: 1996-08-09 Impact factor: 5.157

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Journal: J Neurosci Res Date: 1996-01-15 Impact factor: 4.164

10. APOE genotype-specific differences in the innate immune response.

Authors: Michael P Vitek; Candice M Brown; Carol A Colton
Journal: Neurobiol Aging Date: 2007-12-21 Impact factor: 4.673

26 in total

1. Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain.

Authors: Joshua B Owen; Rukhsana Sultana; Christopher D Aluise; Michelle A Erickson; Tulin O Price; Guojun Bu; William A Banks; D Allan Butterfield
Journal: Free Radic Biol Med Date: 2010-10-07 Impact factor: 7.376

2. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.

Authors: Coralie Brifault; HyoJun Kwon; Wendy M Campana; Steven L Gonias
Journal: Glia Date: 2019-02-11 Impact factor: 7.452

3. Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An ¹⁸F-Fluorodeoxyglucose PET/CT Study.

Authors: Xinghu Qin; Hong You; Fang Cao; Yue Wu; Jianhua Peng; Jinwei Pang; Hong Xu; Yue Chen; Ligang Chen; Michael P Vitek; Fengqiao Li; Xiaochuan Sun; Yong Jiang
Journal: J Neurotrauma Date: 2016-09-27 Impact factor: 5.269

Review 4. Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.

Authors: Michael L James; Jordan M Komisarow; Haichen Wang; Daniel T Laskowitz
Journal: Neurotherapeutics Date: 2020-04 Impact factor: 7.620