PURPOSE: The authors investigate the efficacy of using the cytokine levels and clonal heavy-chain immunoglobulin (IgH) gene rearrangements in the vitreous as adjunctive tools to diagnose intraocular lymphoma (IOL). METHODS: The IL-10 and IL-6 levels and IgH gene rearrangements were analyzed in vitreous samples from 8 cases of IOL and in 14 uveitis patients. RESULTS: The level of IL-10 with an IL-10/IL-6 ratio > 1 was significantly higher in all eyes with IOL. B-cell monoclonality was detected in only 5 of 8 eyes with IOL. CONCLUSIONS: The measurements of the levels of cytokines are valuable as a reliable biomarker.
PURPOSE: The authors investigate the efficacy of using the cytokine levels and clonal heavy-chain immunoglobulin (IgH) gene rearrangements in the vitreous as adjunctive tools to diagnose intraocular lymphoma (IOL). METHODS: The IL-10 and IL-6 levels and IgH gene rearrangements were analyzed in vitreous samples from 8 cases of IOL and in 14 uveitispatients. RESULTS: The level of IL-10 with an IL-10/IL-6 ratio > 1 was significantly higher in all eyes with IOL. B-cell monoclonality was detected in only 5 of 8 eyes with IOL. CONCLUSIONS: The measurements of the levels of cytokines are valuable as a reliable biomarker.
Authors: Laura S Hiemcke-Jiwa; Ninette H Ten Dam-van Loon; Roos J Leguit; Stefan Nierkens; Jeannette Ossewaarde-van Norel; Joke H de Boer; Floor F Roholl; Roel A de Weger; Manon M H Huibers; Jolanda D F de Groot-Mijnes; Jonas J W Kuiper Journal: JAMA Ophthalmol Date: 2018-10-01 Impact factor: 7.389
Authors: Seul Lee; Moon Jin Kim; Jin Seok Kim; Sung Yong Oh; Seok Jin Kim; Yoon Hyung Kwon; In Young Chung; Jung Hun Kang; Deok-Hwan Yang; Hye Jin Kang; Dok Hyun Yoon; Won Seog Kim; Hyo-Jin Kim; Cheolwon Suh Journal: Blood Res Date: 2015-12-21