PURPOSE: To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT. METHODS: Thirty-two eyes from 32 normal patients underwent complete ophthalmic evaluation. Macular scanning using the StratusOCT and the RTVue-100 OCT were performed for a total of three times each on the same visit. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study, along with the foveal center point and macular volume, were recorded. The SD, the coefficient of variation, and the intraclass correlation coefficient were calculated for each parameter studied. Comparisons were made between the two OCTs in terms of retinal thicknesses measurements, their reproducibility, and macular regional differences. Correlations between retinal thickness and demographic variables (age and gender) were also investigated. Due to known differences in segmentation algorithms of the two OCTs, software calipers were used to measure the distance from the internal limiting membrane to the photoreceptor inner segment-outer segment junction at the foveal center point on all RTVue scans to allow a more fair comparison. RESULTS: The RTVue yielded greater retinal thickness measurements in nearly all macular subfields compared with the StratusOCT. Even after accounting for differences in segmentation algorithms, significant disparities were still evident with the RTVue measurements less than those of the StratusOCT at the foveal center. On both machines, the macula was thinnest at the fovea and thickest within the 3 mm ring. There were some consistent regional variations in macular thickness evident on both OCTs. Compared with the StratusOCT, the RTVue generally had lower coefficients of variation and higher intraclass coefficients, suggesting better reproducibility. Age and gender also appeared to be important determinants in some macular thickness parameters. CONCLUSION: Compared with StratusOCT, the RTVue fourier-domain OCT yields greater retinal thickness measurements with greater reproducibility, presumably due to different segmentation algorithms, increased sampling density, and greater resolution. However, regional differences across the macula can be consistently observed with both devices.
PURPOSE: To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT. METHODS: Thirty-two eyes from 32 normal patients underwent complete ophthalmic evaluation. Macular scanning using the StratusOCT and the RTVue-100 OCT were performed for a total of three times each on the same visit. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study, along with the foveal center point and macular volume, were recorded. The SD, the coefficient of variation, and the intraclass correlation coefficient were calculated for each parameter studied. Comparisons were made between the two OCTs in terms of retinal thicknesses measurements, their reproducibility, and macular regional differences. Correlations between retinal thickness and demographic variables (age and gender) were also investigated. Due to known differences in segmentation algorithms of the two OCTs, software calipers were used to measure the distance from the internal limiting membrane to the photoreceptor inner segment-outer segment junction at the foveal center point on all RTVue scans to allow a more fair comparison. RESULTS: The RTVue yielded greater retinal thickness measurements in nearly all macular subfields compared with the StratusOCT. Even after accounting for differences in segmentation algorithms, significant disparities were still evident with the RTVue measurements less than those of the StratusOCT at the foveal center. On both machines, the macula was thinnest at the fovea and thickest within the 3 mm ring. There were some consistent regional variations in macular thickness evident on both OCTs. Compared with the StratusOCT, the RTVue generally had lower coefficients of variation and higher intraclass coefficients, suggesting better reproducibility. Age and gender also appeared to be important determinants in some macular thickness parameters. CONCLUSION: Compared with StratusOCT, the RTVue fourier-domain OCT yields greater retinal thickness measurements with greater reproducibility, presumably due to different segmentation algorithms, increased sampling density, and greater resolution. However, regional differences across the macula can be consistently observed with both devices.
Authors: Wolfgang Drexler; Harald Sattmann; Boris Hermann; Tony H Ko; Michael Stur; Angelika Unterhuber; Christoph Scholda; Oliver Findl; Matthias Wirtitsch; James G Fujimoto; Adolf F Fercher Journal: Arch Ophthalmol Date: 2003-05
Authors: Martin Gloesmann; Boris Hermann; Christian Schubert; Harald Sattmann; Peter K Ahnelt; Wolfgang Drexler Journal: Invest Ophthalmol Vis Sci Date: 2003-04 Impact factor: 4.799
Authors: Christopher Kai-shun Leung; Carol Yim-lui Cheung; Robert N Weinreb; Gary Lee; Dusheng Lin; Chi Pui Pang; Dennis S C Lam Journal: Invest Ophthalmol Vis Sci Date: 2008-04-30 Impact factor: 4.799
Authors: Viviane Guedes; Joel S Schuman; Ellen Hertzmark; Gadi Wollstein; Anthony Correnti; Ronald Mancini; David Lederer; Serineh Voskanian; Leonardo Velazquez; Helena M Pakter; Tamar Pedut-Kloizman; James G Fujimoto; Cynthia Mattox Journal: Ophthalmology Date: 2003-01 Impact factor: 12.079
Authors: Bhavna J Antony; Paul F Stetson; Michael D Abramoff; Kyungmoo Lee; Johanna M Colijn; Gabriëlle H S Buitendijk; Caroline C W Klaver; Austin Roorda; Brandon J Lujan Journal: Transl Vis Sci Technol Date: 2015-07-31 Impact factor: 3.283
Authors: Andrew Lang; Aaron Carass; Matthew Hauser; Elias S Sotirchos; Peter A Calabresi; Howard S Ying; Jerry L Prince Journal: Biomed Opt Express Date: 2013-06-14 Impact factor: 3.732