Literature DB >> 19582422

Neurosphere culture and human organotypic model to evaluate brain tumor stem cells.

Hugo Guerrero-Cázares1, Kaisorn L Chaichana, Alfredo Quiñones-Hinojosa.   

Abstract

The brain tumor stem cell (BTSC) hypothesis is based on the premise that there is a subpopulation of cells within tumors with tumorigenic and pluripotent properties. BTSC are believed to be responsible for both the initiation of brain tumors and their resistance to current therapeutic modalities. This new paradigm stresses the need for adequate techniques to culture and characterize this special population of cells. Furthermore, the use of different cell migration assays offers the possibility to evaluate the processes involved in glioma metastasis. In this chapter, we summarize a method to culture, analyze the cellular characteristics, and study the invasion of BTSCs using a neurosphere assay, cryostat sectioning, and human organotypic brain cortex migration assay, respectively.

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Mesh：

Year:  2009        PMID： 19582422      PMCID： PMC2938041          DOI： 10.1007/978-1-59745-280-9_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  27 in total

1.  Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.

Authors:  Hynek Wichterle; Manuel Alvarez-Dolado; Lynda Erskine; Arturo Alvarez-Buylla
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-06       Impact factor: 11.205

2.  Neurosphere assays: growth factors and hormone differences in tumor and nontumor studies.

Authors:  Kaisorn Chaichana; Grettel Zamora-Berridi; Joaquin Camara-Quintana; Alfredo Quiñones-Hinojosa
Journal:  Stem Cells       Date:  2006-08-31       Impact factor: 6.277

3.  Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology.

Authors:  Ilyas Singec; Rolf Knoth; Ralf P Meyer; Jaroslaw Maciaczyk; Benedikt Volk; Guido Nikkhah; Michael Frotscher; Evan Y Snyder
Journal:  Nat Methods       Date:  2006-10       Impact factor: 28.547

4.  The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation.

Authors:  Lisa M J Lee; Elisabeth A Seftor; Gregory Bonde; Robert A Cornell; Mary J C Hendrix
Journal:  Dev Dyn       Date:  2005-08       Impact factor: 3.780

5.  Clonal analyses and cryopreservation of neural stem cell cultures.

Authors:  Angela Gritti; Rossella Galli; Angelo L Vescovi
Journal:  Methods Mol Biol       Date:  2008

6.  Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma.

Authors:  Graziella Filippini; Chiara Falcone; Amerigo Boiardi; Giovanni Broggi; Maria G Bruzzone; Dario Caldiroli; Rita Farina; Mariangela Farinotti; Laura Fariselli; Gaetano Finocchiaro; Sergio Giombini; Bianca Pollo; Mario Savoiardo; Carlo L Solero; Maria G Valsecchi
Journal:  Neuro Oncol       Date:  2007-11-09       Impact factor: 12.300

7.  Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro.

Authors:  Tatyana N Ignatova; Valery G Kukekov; Eric D Laywell; Oleg N Suslov; Frank D Vrionis; Dennis A Steindler
Journal:  Glia       Date:  2002-09       Impact factor: 7.452

8.  Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases.

Authors:  Kaisorn L Chaichana; Vivian Capilla-Gonzalez; Oscar Gonzalez-Perez; Gustavo Pradilla; James Han; Alessandro Olivi; Henry Brem; Jose Manuel Garcia-Verdugo; Alfredo Quiñones-Hinojosa
Journal:  J Neurosci Methods       Date:  2007-05-16       Impact factor: 2.390

9.  A novel model of glioma cell invasion using organotypic brain slice culture.

Authors:  T Ohnishi; H Matsumura; S Izumoto; S Hiraga; T Hayakawa
Journal:  Cancer Res       Date:  1998-07-15       Impact factor: 12.701

10.  Cancerous stem cells can arise from pediatric brain tumors.

Authors:  Houman D Hemmati; Ichiro Nakano; Jorge A Lazareff; Michael Masterman-Smith; Daniel H Geschwind; Marianne Bronner-Fraser; Harley I Kornblum
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-26       Impact factor: 11.205
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  23 in total

1.  Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development.

Authors:  Hugo Guerrero-Cazares; Emily Lavell; Linda Chen; Paula Schiapparelli; Montserrat Lara-Velazquez; Vivian Capilla-Gonzalez; Anna Christina Clements; Gabrielle Drummond; Liron Noiman; Katrina Thaler; Anne Burke; Alfredo Quiñones-Hinojosa
Journal:  Stem Cells       Date:  2017-04-24       Impact factor: 6.277

2.  Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1.

Authors:  Mingxin Zhu; Yun Feng; Sean Dangelmajer; Hugo Guerrero-Cázares; Kaisorn L Chaichana; Christopher L Smith; Andre Levchenko; Ting Lei; Alfredo Quiñones-Hinojosa
Journal:  Stem Cells Dev       Date:  2015-01-15       Impact factor: 3.272

3.  Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas.

Authors:  Gordon Li; Siddhartha S Mitra; Michelle Monje; Kristy N Henrich; C Dana Bangs; Ryan T Nitta; Albert J Wong
Journal:  J Neurooncol       Date:  2012-03-02       Impact factor: 4.130

4.  Quantification of cellular and nuclear uptake rates of polymeric gene delivery nanoparticles and DNA plasmids via flow cytometry.

Authors:  Corey J Bishop; Rebecca L Majewski; Toni-Rose M Guiriba; David R Wilson; Nupura S Bhise; Alfredo Quiñones-Hinojosa; Jordan J Green
Journal:  Acta Biomater       Date:  2016-03-24       Impact factor: 8.947

Review 5.  Engineering principles for guiding spheroid function in the regeneration of bone, cartilage, and skin.

Authors:  Marissa A Gionet-Gonzales; J Kent Leach
Journal:  Biomed Mater       Date:  2018-03-21       Impact factor: 3.715

6.  Electrophoresis of cell membrane heparan sulfate regulates galvanotaxis in glial cells.

Authors:  Yu-Ja Huang; Paula Schiapparelli; Kristen Kozielski; Jordan Green; Emily Lavell; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa; Peter Searson
Journal:  J Cell Sci       Date:  2017-06-08       Impact factor: 5.285

7.  Glioblastoma heterogeneity and more accurate representation in research models.

Authors:  Hugo Guerrero-Cázares; Linda Chen; Alfredo Quiñones-Hinojosa
Journal:  World Neurosurg       Date:  2011-11-01       Impact factor: 2.104

8.  Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival.

Authors:  Qian Li; Olindi Wijesekera; Sussan J Salas; Joanna Y Wang; Mingxin Zhu; Colette Aprhys; Kaisorn L Chaichana; David A Chesler; Hao Zhang; Christopher L Smith; Hugo Guerrero-Cazares; Andre Levchenko; Alfredo Quinones-Hinojosa
Journal:  Clin Cancer Res       Date:  2014-05-01       Impact factor: 12.531

9.  IL-13Rα2-Targeted Therapy Escapees: Biologic and Therapeutic Implications.

Authors:  Van Nguyen; Jesse M Conyers; Dongqin Zhu; Denise M Gibo; Jay F Dorsey; Waldemar Debinski; Akiva Mintz
Journal:  Transl Oncol       Date:  2011-12-01       Impact factor: 4.243

Review 10.  The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells.

Authors:  Catherine J Libby; Anh Nhat Tran; Sarah E Scott; Corinne Griguer; Anita B Hjelmeland
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2018-01-31       Impact factor: 10.680
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