BACKGROUND: Diabetes mellitus is associated with a variety of musculoskeletal disorders. The prevalence of connective tissue disorders in these patients has increased in the recent years affecting significantly their quality of life. METHODS- RESULTS: We conducted a pilot study including 208 sequentially selected patients with type 2 diabetes mellitus regularly followed-up at the Diabetes Center of the Hippokration University Hospital. Among the diabetic patients who were screened according to the Short Musculoskeletal Function Assessment Questionnaire for musculoskeletal symptoms and findings, 82.6% were found to exhibit musculoskeletal abnormalities, mainly of the degenerative, noninflammatory type. CONCLUSIONS: Musculoskeletal disorders are a common finding among patients with type 2 diabetes. Obesity and accumulation of abnormally glycosylated byproducts have been proposed as potential pathogenetic mediators of these connective tissue abnormalities. Of particular interest is, however, the common association of osteoarthritis, involving even non-weight bearing joints in patients with type 2 diabetes, indicating a common pathophysiologic mechanism connecting these two clinical conditions.
BACKGROUND:Diabetes mellitus is associated with a variety of musculoskeletal disorders. The prevalence of connective tissue disorders in these patients has increased in the recent years affecting significantly their quality of life. METHODS- RESULTS: We conducted a pilot study including 208 sequentially selected patients with type 2 diabetes mellitus regularly followed-up at the Diabetes Center of the Hippokration University Hospital. Among the diabeticpatients who were screened according to the Short Musculoskeletal Function Assessment Questionnaire for musculoskeletal symptoms and findings, 82.6% were found to exhibit musculoskeletal abnormalities, mainly of the degenerative, noninflammatory type. CONCLUSIONS:Musculoskeletal disorders are a common finding among patients with type 2 diabetes. Obesity and accumulation of abnormally glycosylated byproducts have been proposed as potential pathogenetic mediators of these connective tissue abnormalities. Of particular interest is, however, the common association of osteoarthritis, involving even non-weight bearing joints in patients with type 2 diabetes, indicating a common pathophysiologic mechanism connecting these two clinical conditions.
Authors: Alexandros A Andrianakos; Leonidas K Kontelis; Dimitrios G Karamitsos; Spyros I Aslanidis; Athanasios I Georgountzos; George O Kaziolas; Kyriaki V Pantelidou; Elizabeth V Vafiadou; Petros C Dantis Journal: J Rheumatol Date: 2006-12 Impact factor: 4.666
Authors: Mariely Nieves-Plaza; Lesliane E Castro-Santana; Yvonne M Font; Angel M Mayor; Luis M Vilá Journal: J Clin Rheumatol Date: 2013-01 Impact factor: 3.517
Authors: Tariq Ahmed Bhat; Shabir Ahmed Dhar; Tahir Ahmed Dar; Muzzaffar Ahmed Naikoo; Mubarik Ahmed Naqqash; Ajaz Bhat; Mohammed Farooq Butt Journal: Int J Health Sci (Qassim) Date: 2016-01
Authors: Robert A Mooney; Erik R Sampson; Jaclyn Lerea; Randy N Rosier; Michael J Zuscik Journal: Arthritis Res Ther Date: 2011-12-07 Impact factor: 5.156