Literature DB >> 1958219

Squamous cell carcinoma antigen is a new member of the serine protease inhibitors.

Y Suminami1, F Kishi, K Sekiguchi, H Kato.   

Abstract

We have cloned cDNA of squamous cell carcinoma antigen. Sequence analysis of the complete 1711 basepairs SCC antigen cDNA revealed that it coded 390 amino acids and no typical signal sequence in the NH2-terminus. Northern blot analysis of human squamous cell poly(A)+ RNA using this cDNA insert as the probe showed a single RNA species of about 1.7 kilobases. The cDNA was expressed in Escherichia coli and the product was detected by immunological methods using antibodies against SCC antigen, indicating that this cDNA encodes the entire SCC antigen sequence. The amino acid homology search revealed that SCC antigen was a member of the serine protease inhibitors family.

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Year:  1991        PMID： 1958219     DOI： 10.1016/s0006-291x(05)81380-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  41 in total

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2.  Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

Authors:  Erica Ullman; Ji-An Pan; Wei-Xing Zong
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Review 3.  Deciphering the mystery of hepatitis B virus receptors: A historical perspective.

Authors:  Zaira Rehman; Ammad Fahim; Hajra Sadia
Journal:  Virusdisease       Date:  2015-07-03

4.  Hydrophobicity of reactive site loop of SCCA1 affects its binding to hepatitis B virus.

Authors:  Min Chen; Tong Cheng; Chen-Yu Xu; Ting Wu; Shan-Hai Ou; Tao Zhang; Jun Zhang; Ning-Shao Xia
Journal:  World J Gastroenterol       Date:  2005-05-21       Impact factor: 5.742

5.  Tissue expression of squamous cellular carcinoma antigen and Ki67 in hepatocellular carcinoma-correlation with prognosis: a historical prospective study.

Authors:  Hemda Schmilovitz-Weiss; Ana Tobar; Marisa Halpern; Izhar Levy; Esther Shabtai; Ziv Ben-Ari
Journal:  Diagn Pathol       Date:  2011-12-07       Impact factor: 2.644

Review 6.  Clinical applications of squamous cell carcinoma antigen-immunoglobulins M to monitor chronic hepatitis C.

Authors:  Andrea Martini; Andrea Gallotta; Patrizia Pontisso; Giorgio Fassina
Journal:  World J Hepatol       Date:  2015-12-18

7.  Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

Authors:  Simi T Ahmed; James E Darnell
Journal:  Biochem Biophys Res Commun       Date:  2008-12-12       Impact factor: 3.575

8.  Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma.

Authors:  Magdalena Chechlinska; Magdalena Kowalewska; Edyta Brzoska-Wojtowicz; Jakub Radziszewski; Konrad Ptaszynski; Janusz Rys; Janina Kaminska; Radoslawa Nowak
Journal:  Tumour Biol       Date:  2010-07-01

9.  A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

Authors:  S S Schneider; C Schick; K E Fish; E Miller; J C Pena; S D Treter; S M Hui; G A Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

10.  Biomarkers in cervical cancer.

Authors:  Eun-Kyoung Yim; Jong-Sup Park
Journal:  Biomark Insights       Date:  2007-02-07
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