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Literature DB >> 19070595

Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

Abstract

Persistently activated STAT3 contributes to cell survival in many different human cancers. Cancer cell secretion of IL-6 is a frequent basis for persistent STAT3 activation; we show that antibodies against IL-6 or gp-130, the signaling unit of the IL-6 receptor, can abruptly remove persistently activated STAT3 causing prompt disappearance of cysteine proteases of serpin B3/B4 mRNAs, known as squamous cell carcinoma antigens 1 and 2. STAT3 occupies the promoter of serpin B3/B4 before removal and siRNA removal of B3/B4 mRNA caused cell death in HN13 head and neck cancer cells. Thus persistently activated STAT3 is a required part of the continuous activation of B3/B4 genes, which protects tumor cells from dying.

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Year: 2008 PMID： 19070595 PMCID： PMC2678569 DOI： 10.1016/j.bbrc.2008.11.147

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

Review 1. Stats: transcriptional control and biological impact.

Review 2. The STATs of cancer--new molecular targets come of age.

3. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

4. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

5. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

6. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

7. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Review 8. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

9. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

10. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

1. Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver.

Review 2. SERPINB3 and B4: From biochemistry to biology.

3. Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.

4. SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3).

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