Literature DB >> 19581462

Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates.

Yu Min Ho1, Yong-Jiang Sun, Sin-Yew Wong, Ann S G Lee.   

Abstract

Screening of 127 isoniazid (INH)-resistant Mycobacterium tuberculosis isolates from Singapore for mutations within the dfrA and inhA genes revealed mutations in 0 and 5 (3.9%) isolates respectively, implying that mutations in dfrA do not contribute to the detection of INH-resistant M. tuberculosis and that mutations within inhA are rare. Thirty-seven (29%) of the 127 isolates had no mutations in any of the genes implicated in INH resistance (katG, kasA, and ndh; inhA and ahpC promoters), suggesting that there are new INH targets yet to be discovered.

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Year:  2009        PMID： 19581462      PMCID： PMC2737874          DOI： 10.1128/AAC.00433-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

Review 1.  Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.

Authors:  S Ramaswamy; J M Musser
Journal:  Tuber Lung Dis       Date:  1998

Review 2.  Resistance to antitubercular drugs.

Authors:  L A Basso; J S Blanchard
Journal:  Adv Exp Med Biol       Date:  1998       Impact factor: 2.622

3.  Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level.

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Journal:  J Clin Microbiol       Date:  1997-03       Impact factor: 5.948

4.  Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

Authors:  D R Sherman; K Mdluli; M J Hickey; T M Arain; S L Morris; C E Barry; C K Stover
Journal:  Science       Date:  1996-06-14       Impact factor: 47.728

5.  Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.

Authors:  A S Lee; A S Teo; S Y Wong
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

6.  Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance.

Authors:  T C Victor; A van Rie; A M Jordaan; M Richardson; G D van Der Spuy; N Beyers; P D van Helden; R Warren
Journal:  J Clin Microbiol       Date:  2001-11       Impact factor: 5.948

7.  Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.

Authors:  S Morris; G H Bai; P Suffys; L Portillo-Gomez; M Fairchok; D Rouse
Journal:  J Infect Dis       Date:  1995-04       Impact factor: 5.226

8.  Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  D A Rouse; Z Li; G H Bai; S L Morris
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

9.  inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.

Authors:  A Banerjee; E Dubnau; A Quemard; V Balasubramanian; K S Um; T Wilson; D Collins; G de Lisle; W R Jacobs
Journal:  Science       Date:  1994-01-14       Impact factor: 47.728

10.  The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.

Authors:  Y Zhang; B Heym; B Allen; D Young; S Cole
Journal:  Nature       Date:  1992-08-13       Impact factor: 49.962
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  12 in total

1.  Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance.

Authors:  Claudio U Köser; Richard N Veerapen-Pierce; David K Summers; John A C Archer
Journal:  Antimicrob Agents Chemother       Date:  2010-10       Impact factor: 5.191

2.  Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling.

Authors:  Griselda Tudó; Ken Laing; Denis A Mitchison; Philip D Butcher; Simon J Waddell
Journal:  Future Med Chem       Date:  2010-08       Impact factor: 3.808

3.  Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  F Brossier; N Veziris; C Truffot-Pernot; V Jarlier; W Sougakoff
Journal:  Antimicrob Agents Chemother       Date:  2010-10-25       Impact factor: 5.191

4.  Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

Authors:  Feng Wang; Paras Jain; Gulcin Gulten; Zhen Liu; Yicheng Feng; Krishna Ganesula; Alifiya S Motiwala; Thomas R Ioerger; David Alland; Catherine Vilchèze; William R Jacobs; James C Sacchettini
Journal:  Antimicrob Agents Chemother       Date:  2010-06-21       Impact factor: 5.191

5.  Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis.

Authors:  Nada Lelovic; Katsuhiko Mitachi; Junshu Yang; Maddie R Lemieux; Yinduo Ji; Michio Kurosu
Journal:  J Antibiot (Tokyo)       Date:  2020-05-29       Impact factor: 2.649

6.  Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis.

Authors:  Danny C T Ong; Wing-Cheong Yam; Gilman K H Siu; Ann S G Lee
Journal:  J Clin Microbiol       Date:  2010-02-17       Impact factor: 5.948

7.  Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.

Authors:  L T Daum; G W Fischer; J Sromek; M Khubbar; P Hunter; M S Gradus; S Bhattacharyya
Journal:  Epidemiol Infect       Date:  2013-09-27       Impact factor: 2.451

8.  Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.

Authors:  Navisha Dookie; A Willem Sturm; Prashini Moodley
Journal:  BMC Infect Dis       Date:  2016-10-26       Impact factor: 3.090

9.  Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.

Authors:  Vivek Kumar; M Elizabeth Sobhia
Journal:  PLoS One       Date:  2015-12-14       Impact factor: 3.240

Review 10.  Drug Resistance Mechanisms in Mycobacterium tuberculosis.

Authors:  Juan Carlos Palomino; Anandi Martin
Journal:  Antibiotics (Basel)       Date:  2014-07-02
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