BACKGROUND: Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT). METHODS: Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day. RESULTS: The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25-49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31-75), 50 (30-70), and 45 (36-50) min, respectively. The median increase in glucose during OGTT was 45 (35-66) mg/dL, and that after breakfast, lunch and dinner was 21 (12-32), 37 (27-48), and 44 (25-63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = -0.46, P = 0.025) and had smaller glucose increments during OGTT (r = -0.49, P = 0.014). CONCLUSIONS: This study is the first report to document the glucose profile of Asian people with NGT.
BACKGROUND: Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT). METHODS:Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day. RESULTS: The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25-49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31-75), 50 (30-70), and 45 (36-50) min, respectively. The median increase in glucose during OGTT was 45 (35-66) mg/dL, and that after breakfast, lunch and dinner was 21 (12-32), 37 (27-48), and 44 (25-63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = -0.46, P = 0.025) and had smaller glucose increments during OGTT (r = -0.49, P = 0.014). CONCLUSIONS: This study is the first report to document the glucose profile of Asian people with NGT.
Authors: Helena Mendes-Soares; Tali Raveh-Sadka; Shahar Azulay; Kim Edens; Yatir Ben-Shlomo; Yossi Cohen; Tal Ofek; Davidi Bachrach; Josh Stevens; Dorin Colibaseanu; Lihi Segal; Purna Kashyap; Heidi Nelson Journal: JAMA Netw Open Date: 2019-02-01
Authors: Marjan Alssema; Hanny M Boers; Antonio Ceriello; Eric S Kilpatrick; David J Mela; Marion G Priebe; Patrick Schrauwen; Bruce H Wolffenbuttel; Andreas F H Pfeiffer Journal: Br J Nutr Date: 2014-12-11 Impact factor: 3.718