Literature DB >> 19580307

Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations.

Christina Despotopoulou1, Lydia Klier, Paul Knochel.   

Abstract

The full functionalization of the pyrazole ring was achieved by successive regioselective metalations using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl. Trapping with various electrophiles led to trisubstituted pyrazoles. An application to the synthesis of the acaricide Tebufenpyrad is reported.

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Year:  2009        PMID： 19580307     DOI： 10.1021/ol901208d

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.

Authors:  David J Babinski; Hector R Aguilar; Raymond Still; Doug E Frantz
Journal:  J Org Chem       Date:  2011-06-27       Impact factor: 4.354

2.  Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.

Authors:  Xinfang Xu; Peter Y Zavalij; Wenhao Hu; Michael P Doyle
Journal:  J Org Chem       Date:  2013-01-24       Impact factor: 4.354

3.  Construction of hybrid polycyclic quinolinobenzo[a]phenazinone architectures using solid-state melt reaction (SSMR).

Authors:  Manickam Bakthadoss; Varathan Vinayagam
Journal:  Mol Divers       Date:  2020-05-04       Impact factor: 2.943

4.  Selective Functionalization of Tetrathiafulvalene Using Mg- and Zn-TMP-Bases: Preparation of Mono-, Di-, Tri-, and Tetrasubstituted Derivatives.

Authors:  Julia Nafe; Florian Auras; Konstantin Karaghiosoff; Thomas Bein; Paul Knochel
Journal:  Org Lett       Date:  2015-10-15       Impact factor: 6.005

5.  Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents.

Authors:  Josef Jansa; Ramona Schmidt; Ashenafi Damtew Mamuye; Laura Castoldi; Alexander Roller; Vittorio Pace; Wolfgang Holzer
Journal:  Beilstein J Org Chem       Date:  2017-05-12       Impact factor: 2.883

6.  Cascade annulation reaction (CAR): highly diastereoselective synthesis of pyranopyrazole scaffolds.

Authors:  Manickam Bakthadoss; Manickam Surendar
Journal:  RSC Adv       Date:  2020-05-19       Impact factor: 4.036
  6 in total

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