AIM: To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis. RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P = 0.047, P = 0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P = 0.003, P = 0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P = 0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.
AIM: To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis. RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P = 0.047, P = 0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P = 0.003, P = 0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P = 0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.
Authors: Marco Niedergethmann; Ralf Hildenbrand; Birgit Wostbrock; Mark Hartel; Jörg W Sturm; Axel Richter; Stefan Post Journal: Pancreas Date: 2002-08 Impact factor: 3.327
Authors: S K Ellika; R Jain; S C Patel; L Scarpace; L R Schultz; J P Rock; T Mikkelsen Journal: AJNR Am J Neuroradiol Date: 2007-09-24 Impact factor: 3.825
Authors: Michael I Koukourakis; Ioannis Mavanis; George Kouklakis; Michael Pitiakoudis; George Minopoulos; Costantinos Manolas; Costantinos Simopoulos Journal: Am J Clin Oncol Date: 2007-06 Impact factor: 2.339
Authors: G Fontanini; P Faviana; M Lucchi; L Boldrini; A Mussi; T Camacci; M A Mariani; C A Angeletti; F Basolo; R Pingitore Journal: Br J Cancer Date: 2002-02-12 Impact factor: 7.640
Authors: E Belousova; G Karmazanovsky; A Kriger; D Kalinin; L Mannelli; A Glotov; N Karelskaya; O Paklina; A Kaldarov Journal: Clin Radiol Date: 2016-11-24 Impact factor: 2.350
Authors: Daniel V T Catenacci; Melissa R Junttila; Theodore Karrison; Nathan Bahary; Margit N Horiba; Sreenivasa R Nattam; Robert Marsh; James Wallace; Mark Kozloff; Lakshmi Rajdev; Deirdre Cohen; James Wade; Bethany Sleckman; Heinz-Josef Lenz; Patrick Stiff; Pankaj Kumar; Peng Xu; Les Henderson; Naoko Takebe; Ravi Salgia; Xi Wang; Walter M Stadler; Frederic J de Sauvage; Hedy L Kindler Journal: J Clin Oncol Date: 2015-11-02 Impact factor: 44.544