| Literature DB >> 19574343 |
Jiyoung Ahn1, Fredrick R Schumacher, Sonja I Berndt, Ruth Pfeiffer, Demetrius Albanes, Gerald L Andriole, Eva Ardanaz, Heiner Boeing, Bas Bueno-de-Mesquita, Stephen J Chanock, Françoise Clavel-Chapelon, W Ryan Diver, Heather Spencer Feigelson, J Michael Gaziano, Edward Giovannucci, Christopher A Haiman, Brian E Henderson, Robert N Hoover, Laurence N Kolonel, Peter Kraft, Jing Ma, Loïc Le Marchand, Kim Overvad, Domenico Palli, Pär Stattin, Meir Stampfer, Daniel O Stram, Gilles Thomas, Michael J Thun, Ruth C Travis, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J Weinstein, Meredith Yeager, Rudolf Kaaks, David J Hunter, Richard B Hayes.
Abstract
Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.Entities:
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Year: 2009 PMID： 19574343 PMCID： PMC2742399 DOI： 10.1093/hmg/ddp302
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150