OBJECTIVE: The aim of this study was to evaluate the effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: In this pilot study, 60 infertile PCOS patients were enrolled in a randomized clinical trial and divided into three equal groups. Group 1 received 1,000 mg of calcium and 400 IU of vitamin D per day, orally. Group 2 received the same as Group 1, plus 1,500 mg/day of metformin. Group 3 received 1,500 mg/day of metformin. The patients were treated for 3 months and followed up for a further 3 months. Regularity of menses, number of large follicles (> or = 14 mm) and pregnancy rates were compared among the three groups. RESULTS: Generalized estimating equation tests showed that the number of dominant follicles (> or = 14 mm) during the 2-3 months of follow-up was higher in the calcium-vitamin D plus metformin group than in either of the other two groups (p = 0.03). CONCLUSION: The effects of metformin and calcium-vitamin D in regulating the menstrual cycle suggest that they could also be effective for the treatment of anovulation and oligomenorrhea, with possible consequences for pregnancy rates in PCOS patients.
RCT Entities:
OBJECTIVE: The aim of this study was to evaluate the effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: In this pilot study, 60 infertile PCOSpatients were enrolled in a randomized clinical trial and divided into three equal groups. Group 1 received 1,000 mg of calcium and 400 IU of vitamin D per day, orally. Group 2 received the same as Group 1, plus 1,500 mg/day of metformin. Group 3 received 1,500 mg/day of metformin. The patients were treated for 3 months and followed up for a further 3 months. Regularity of menses, number of large follicles (> or = 14 mm) and pregnancy rates were compared among the three groups. RESULTS: Generalized estimating equation tests showed that the number of dominant follicles (> or = 14 mm) during the 2-3 months of follow-up was higher in the calcium-vitamin D plus metformin group than in either of the other two groups (p = 0.03). CONCLUSION: The effects of metformin and calcium-vitamin D in regulating the menstrual cycle suggest that they could also be effective for the treatment of anovulation and oligomenorrhea, with possible consequences for pregnancy rates in PCOSpatients.
Authors: M Chakhtoura; E A Akl; S El Ghandour; K Shawwa; A Arabi; Z Mahfoud; R H Habib; H Hoballah; G El Hajj Fuleihan Journal: Osteoporos Int Date: 2016-11-22 Impact factor: 4.507
Authors: Lubna Pal; Heping Zhang; Joanne Williams; Nanette F Santoro; Michael P Diamond; William D Schlaff; Christos Coutifaris; Sandra A Carson; Michael P Steinkampf; Bruce R Carr; Peter G McGovern; Nicholas A Cataldo; Gabriella G Gosman; John E Nestler; Evan Myers; Richard S Legro Journal: J Clin Endocrinol Metab Date: 2016-05-17 Impact factor: 5.958