Literature DB >> 19573884

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort.

Laura J Rasmussen-Torvik1, James S Pankow, David R Jacobs, Alan R Sinaiko.   

Abstract

There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy whites (from 226 families) and 89 African Americans (from 48 families) were included in the analysis. No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups.

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Year:  2009        PMID： 19573884      PMCID： PMC2748141          DOI： 10.1016/j.metabol.2009.04.023

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  8 in total

1.  Heritability and genetic correlations of insulin sensitivity measured by the euglycaemic clamp.

Authors:  L J Rasmussen-Torvik; J S Pankow; D R Jacobs; L M Steffen; A M Moran; J Steinberger; A R Sinaiko
Journal:  Diabet Med       Date:  2007-11       Impact factor: 4.359

2.  Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.

Authors:  Lise Wegner; Meena S Hussain; Kasper Pilgaard; Torben Hansen; Oluf Pedersen; Allan Vaag; Pernille Poulsen
Journal:  J Clin Endocrinol Metab       Date:  2008-07-08       Impact factor: 5.958

3.  Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors.

Authors:  A R Sinaiko; D R Jacobs; J Steinberger; A Moran; R Luepker; A P Rocchini; R J Prineas
Journal:  J Pediatr       Date:  2001-11       Impact factor: 4.406

4.  Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

Authors:  Coleen M Damcott; Toni I Pollin; Laurie J Reinhart; Sandra H Ott; Haiqing Shen; Kristi D Silver; Braxton D Mitchell; Alan R Shuldiner
Journal:  Diabetes       Date:  2006-09       Impact factor: 9.461

5.  Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.

Authors:  S C Elbein; W S Chu; S K Das; A Yao-Borengasser; S J Hasstedt; H Wang; N Rasouli; P A Kern
Journal:  Diabetologia       Date:  2007-06-20       Impact factor: 10.122

6.  Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

Authors:  Nicholette D Palmer; Allison B Lehtinen; Carl D Langefeld; Joel K Campbell; Steven M Haffner; Jill M Norris; Richard N Bergman; Mark O Goodarzi; Jerome I Rotter; Donald W Bowden
Journal:  J Clin Endocrinol Metab       Date:  2007-10-30       Impact factor: 5.958

7.  Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

Authors:  A Dahlgren; B Zethelius; K Jensevik; A-C Syvänen; C Berne
Journal:  Diabetologia       Date:  2007-07-06       Impact factor: 10.122

8.  Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Authors:  S A Schäfer; O Tschritter; F Machicao; C Thamer; N Stefan; B Gallwitz; J J Holst; J M Dekker; L M 't Hart; L M t'Hart; G Nijpels; T W van Haeften; H U Häring; A Fritsche
Journal:  Diabetologia       Date:  2007-07-28       Impact factor: 10.122
  8 in total
  8 in total

1.  Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.

Authors:  A P Gjesing; L L Kjems; M A Vestmar; N Grarup; A Linneberg; C F Deacon; J J Holst; O Pedersen; T Hansen
Journal:  Diabetologia       Date:  2010-10-19       Impact factor: 10.122

2.  Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects.

Authors:  Jon D Adams; Aoife M Egan; Marcello C Laurenti; Daniel Schembri Wismayer; Kent R Bailey; Claudio Cobelli; Chiara Dalla Man; Adrian Vella
Journal:  Am J Physiol Endocrinol Metab       Date:  2021-10-18       Impact factor: 4.310

3.  The Effect of Diabetes-Associated Variation in TCF7L2 on Postprandial Glucose Metabolism When Glucagon and Insulin Concentrations Are Matched.

Authors:  Jon D Adams; Aoife M Egan; Marcello C Laurenti; Daniel Schembri Wismayer; Kent R Bailey; Claudio Cobelli; Chiara Dalla Man; Adrian Vella
Journal:  Metab Syndr Relat Disord       Date:  2022-04-18       Impact factor: 2.363

4.  LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Authors:  Rajvir Singh; Renata Belfort De Aguiar; Sarita Naik; Sheida Mani; Kamal Ostadsharif; Detlef Wencker; Masoud Sotoudeh; Reza Malekzadeh; Robert S Sherwin; Arya Mani
Journal:  Cell Metab       Date:  2013-02-05       Impact factor: 27.287

Review 5.  What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?

Authors:  J D Adams; Adrian Vella
Journal:  Metab Syndr Relat Disord       Date:  2018-07-11       Impact factor: 1.894

6.  Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance.

Authors:  Ron T Varghese; Ivan Viegas; Cristina Barosa; Catia Marques; Meera Shah; Robert A Rizza; John G Jones; Adrian Vella
Journal:  Diabetes       Date:  2016-01-28       Impact factor: 9.461

7.  TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.

Authors:  Edmond K Kabagambe; Stephen P Glasser; Jose M Ordovas; Daruneewan Warodomwichit; Michael Y Tsai; Paul N Hopkins; Ingrid B Borecki; Mary Wojczynski; Donna K Arnett
Journal:  Diabetol Metab Syndr       Date:  2009-10-12       Impact factor: 3.320

8.  TCF7L2 polymorphism is associated with low nitric oxide release, endothelial dysfunction and enhanced inflammatory response after myocardial infarction.

Authors:  Riobaldo Cintra; Filipe A Moura; Luiz S F Carvalho; Mauricio Daher; Simone N Santos; Ana P R Costa; Valeria N Figueiredo; Joalbo M Andrade; Francisco A R Neves; Jose C Quinaglia E Silva; Andrei C Sposito
Journal:  BBA Clin       Date:  2016-04-02
  8 in total

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