Literature DB >> 19573579

Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia.

Jianming Wu1, Jian Li, Zhiyong Zhu, Jiang Li, Guojun Huang, Yao Tang, Xiaoping Gao.   

Abstract

Echinocystic acid (EA), a pentacyclic triterpene, was isolated and identified from the fruits of Gleditsia sinensis Lam. The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin. In the electrocardiogram of anesthetized rats, EA prevented the ST-segment depression induced by isoproterenol or vasopressin in a dose-dependently manner. Furthermore, the mRNA expression of Bcl-2 was analyzed by RT-PCR. EA shows an elevation of Bcl-2 mRNA level in infarcted tissue induced by isoproterenol in rats. These results demonstrated for the first time EA has a cardioprotective effect and may be a natural drug.

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Year:  2009        PMID： 19573579     DOI： 10.1016/j.fitote.2009.06.015

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  7 in total

1.  Microbe-mediate transformation of echinocystic acid by whole cells of filamentous fungus Cunninghamella blakesleana CGMCC 3.910.

Authors:  Shaobin Fu; Xu Feng; Di-An Sun
Journal:  Mol Biol Rep       Date:  2018-09-07       Impact factor: 2.316

2.  Echinocystic acid provides a neuroprotective effect via the PI3K/AKT pathway in intracerebral haemorrhage mice.

Authors:  Beilei Chen; Yuanyuan Zhao; Wei Li; Jing Hang; Mengmei Yin; Hailong Yu
Journal:  Ann Transl Med       Date:  2020-01

3.  Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats.

Authors:  Ya-Ting Deng; Wen-Bo Kang; Jian-Ning Zhao; Gang Liu; Ming-Gao Zhao
Journal:  PLoS One       Date:  2015-08-28       Impact factor: 3.240

4.  Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo.

Authors:  Jin-Mu Yi; Jong-Shik Park; Se-Mi Oh; Jun Lee; Jinhee Kim; Dal-Seok Oh; Ok-Sun Bang; No Soo Kim
Journal:  BMC Complement Altern Med       Date:  2012-12-04       Impact factor: 3.659

5.  Deciphering molecular mechanism underlying hypolipidemic activity of echinocystic Acid.

Authors:  Li Han; Peng Lai; Jun-Rong Du
Journal:  Evid Based Complement Alternat Med       Date:  2014-02-11       Impact factor: 2.629

6.  Inhibitory effect of cinobufagin on L-type Ca2+ currents, contractility, and Ca2+ homeostasis of isolated adult rat ventricular myocytes.

Authors:  Pinya Li; Qiongtao Song; Tao Liu; Zhonglin Wu; Xi Chu; Xuan Zhang; Ying Zhang; Yonggang Gao; Jianping Zhang; Li Chu
Journal:  ScientificWorldJournal       Date:  2014-05-25

7.  Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-κB and CYP1A1.

Authors:  Chuan-Feng Huang; Wei-Na Wang; Cheng-Cao Sun; Yu-Qing Wang; Ling Li; Yin Li; De-Jia Li
Journal:  Exp Ther Med       Date:  2017-09-01       Impact factor: 2.447
  7 in total

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