Literature DB >> 1957347

The insulin A and B chains contain sufficient structural information to form the native molecule.

C C Wang1, C L Tsou.   

Abstract

Refolding studies show that native insulin can be reformed from A and B chains only. This suggests that the A and B chains contain the necessary structural information and that the C peptide is not required for this process.

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Year:  1991        PMID： 1957347     DOI： 10.1016/0968-0004(91)90114-b

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  16 in total

1.  A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.

Authors:  Bin Xu; Qing-Xin Hua; Satoe H Nakagawa; Wenhua Jia; Ying-Chi Chu; Panayotis G Katsoyannis; Michael A Weiss
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2.  Contribution of the conserved A16Leu to insulin foldability.

Authors:  Zhao-Jun Zhang; Lan Wu; Zhi-Song Qiao; Ming-Qiang Qiao; You-Min Feng; Zhan-Yun Guo
Journal:  Protein J       Date:  2008-04       Impact factor: 2.371

3.  Both the isomerase and chaperone activities of protein disulfide isomerase are required for the reactivation of reduced and denatured acidic phospholipase A2.

Authors:  Y Yao; Y Zhou; C Wang
Journal:  EMBO J       Date:  1997-02-03       Impact factor: 11.598

Review 4.  A thing of beauty: Structure and function of insulin's "aromatic triplet".

Authors:  Michael A Weiss; Michael C Lawrence
Journal:  Diabetes Obes Metab       Date:  2018-09       Impact factor: 6.577

5.  "Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.

Authors:  Nischay K Rege; Ming Liu; Balamurugan Dhayalan; Yen-Shan Chen; Nicholas A Smith; Leili Rahimi; Jinhong Sun; Huan Guo; Yanwu Yang; Leena Haataja; Nelson F B Phillips; Jonathan Whittaker; Brian J Smith; Peter Arvan; Faramarz Ismail-Beigi; Michael A Weiss
Journal:  J Biol Chem       Date:  2020-01-31       Impact factor: 5.157

Review 6.  Insulin: a small protein with a long journey.

Authors:  Qingxin Hua
Journal:  Protein Cell       Date:  2010-06       Impact factor: 14.870

7.  Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain.

Authors:  Satoe H Nakagawa; Ming Zhao; Qing-xin Hua; Shi-Quan Hu; Zhu-li Wan; Wenhua Jia; Michael A Weiss
Journal:  Biochemistry       Date:  2005-04-05       Impact factor: 3.162

8.  A peptide model of insulin folding intermediate with one disulfide.

Authors:  Han Yan; Zhan-Yun Guo; Xiao-Wen Gong; Dan Xi; You-Min Feng
Journal:  Protein Sci       Date:  2003-04       Impact factor: 6.725

9.  Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry.

Authors:  Alok K Sharma; Yan Ling; Allison B Greer; David A Hafler; Sally C Kent; Yong Zhang; Alan C Rigby
Journal:  J Phys Chem B       Date:  2010-01-14       Impact factor: 2.991

10.  Peptide models of four possible insulin folding intermediates with two disulfides.

Authors:  Xiao-Yuan Jia; Zhan-Yun Guo; Yao Wang; Ye Xu; Shun-Shan Duan; You-Min Feng
Journal:  Protein Sci       Date:  2003-11       Impact factor: 6.725
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