V Dandois1, D Rommel, L Renard, J Jamart, G Cosnard. 1. Department of Medical Imaging, MRI Unit, cliniques universitaires Saint-Luc, université catholique de Louvain, 10, avenue Hippocrate, 1200 Brussels, Belgium. vinciane.dandois@advalvas.be
Abstract
PURPOSE: Our aim was to compare perfusion magnetic resonance imaging (MRI) and positron emission tomography (PET) using carbon-11 labelled methionine (MET) in gliomas and their value in differentiating tumour recurrence from necrosis. MATERIALS AND METHODS: We retrospectively reviewed 28 patients with a high-grade glioma. A total of 33MR perfusions and MET-PET were ultimately analysable for comparison between the relative cerebral blood volume (rCBV) and MET-PET examinations. Intra- and interobserver reproducibility was assessed and diagnostic value of rCBV compared to MET-PET and histology was assessed by the area under the receiver operating characteristic (ROC) curve. RESULTS: ROC curve analysis showed that rCBV had at least equal performances in differentiating tumour recurrence and necrosis than MET-PET. Cut-off value of rCBV for differentiating tumour from necrosis was 182% with a sensitivity of 81.5% and a specificity of 100%. CONCLUSION: In clinical practice, perfusion MRI could replace MET-PET for differentiating necrosis from tumour recurrence. Copyright 2009 Elsevier Masson SAS. All rights reserved.
PURPOSE: Our aim was to compare perfusion magnetic resonance imaging (MRI) and positron emission tomography (PET) using carbon-11 labelled methionine (MET) in gliomas and their value in differentiating tumour recurrence from necrosis. MATERIALS AND METHODS: We retrospectively reviewed 28 patients with a high-grade glioma. A total of 33MR perfusions and MET-PET were ultimately analysable for comparison between the relative cerebral blood volume (rCBV) and MET-PET examinations. Intra- and interobserver reproducibility was assessed and diagnostic value of rCBV compared to MET-PET and histology was assessed by the area under the receiver operating characteristic (ROC) curve. RESULTS: ROC curve analysis showed that rCBV had at least equal performances in differentiating tumour recurrence and necrosis than MET-PET. Cut-off value of rCBV for differentiating tumour from necrosis was 182% with a sensitivity of 81.5% and a specificity of 100%. CONCLUSION: In clinical practice, perfusion MRI could replace MET-PET for differentiating necrosis from tumour recurrence. Copyright 2009 Elsevier Masson SAS. All rights reserved.
Authors: Francesco Cicone; Christian P Filss; Giuseppe Minniti; Camilla Rossi-Espagnet; Annalisa Papa; Claudia Scaringi; Norbert Galldiks; Alessandro Bozzao; N Jon Shah; Francesco Scopinaro; Karl-Josef Langen Journal: Eur J Nucl Med Mol Imaging Date: 2015-03-07 Impact factor: 9.236
Authors: Andor W J M Glaudemans; Roelien H Enting; Mart A A M Heesters; Rudi A J O Dierckx; Ronald W J van Rheenen; Annemiek M E Walenkamp; Riemer H J A Slart Journal: Eur J Nucl Med Mol Imaging Date: 2012-12-12 Impact factor: 9.236
Authors: Otto M Henriksen; Vibeke A Larsen; Aida Muhic; Adam E Hansen; Henrik B W Larsson; Hans S Poulsen; Ian Law Journal: Eur J Nucl Med Mol Imaging Date: 2015-09-12 Impact factor: 9.236