PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS: PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(-1) 100 ml(-1) for PET and 78.9 ± 41.8 ml min(-1) 100 ml(-1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(-1) 100 ml(-1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(-1) 100 ml(-1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours.
PURPOSE:Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCTrCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS:PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(-1) 100 ml(-1) for PET and 78.9 ± 41.8 ml min(-1) 100 ml(-1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(-1) 100 ml(-1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(-1) 100 ml(-1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBFPCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours.
Authors: Janice A Nagy; Sung-Hee Chang; Shou-Ching Shih; Ann M Dvorak; Harold F Dvorak Journal: Semin Thromb Hemost Date: 2010-05-20 Impact factor: 4.180
Authors: T Sugahara; Y Korogi; S Tomiguchi; Y Shigematsu; I Ikushima; T Kira; L Liang; Y Ushio; M Takahashi Journal: AJNR Am J Neuroradiol Date: 2000-05 Impact factor: 4.966
Authors: Ashley M Groves; Gordon C Wishart; Manu Shastry; Penelope Moyle; Sharon Iddles; Peter Britton; Mathew Gaskarth; Ruth M Warren; Peter J Ell; Kenneth A Miles Journal: Eur J Nucl Med Mol Imaging Date: 2008-09-26 Impact factor: 9.236
Authors: Andreas Kjær; Annika Loft; Ian Law; Anne Kiil Berthelsen; Lise Borgwardt; Johan Löfgren; Camilla Bardram Johnbeck; Adam Espe Hansen; Sune Keller; Søren Holm; Liselotte Højgaard Journal: MAGMA Date: 2012-12-25 Impact factor: 2.310