Literature DB >> 19560916

Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.

Paweł Zajdel1, Gilles Subra, Pascal Verdie, Ewa Gabzdyl, Andrzej J Bojarski, Beata Duszyńska, Jean Martinez, Maciej Pawłowski.   

Abstract

A series of arylsulfonamides containing guanidine incorporated in the structure of secondary amines (piperidine, piperazine) was synthesized on SynPhase Lanterns and evaluated for 5-HT(1A), 5-HT(2A), and 5-HT(7) receptors. The results demonstrated that N-alkyl-N'-dialkylguanidines displayed good 5-HT(7)/5-HT(1A) selectivity and may be regarded as promising structural core for development of 5-HT(7) ligands.

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Year:  2009        PMID： 19560916     DOI： 10.1016/j.bmcl.2009.06.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.

Authors:  Marcello Leopoldo; Enza Lacivita; Francesco Berardi; Roberto Perrone; Peter B Hedlund
Journal:  Pharmacol Ther       Date:  2010-10-20       Impact factor: 12.310

Review 2.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

3.  Small-Molecule Library Synthesis on Silicon-Functionalized SynPhase Lanterns.

Authors:  Jeremy R Duvall; Anita Vrcic; Lisa A Marcaurelle
Journal:  Curr Protoc Chem Biol       Date:  2010-07-01

4.  An Algorithm to Identify Target-Selective Ligands - A Case Study of 5-HT7/5-HT1A Receptor Selectivity.

Authors:  Rafał Kurczab; Vittorio Canale; Paweł Zajdel; Andrzej J Bojarski
Journal:  PLoS One       Date:  2016-06-07       Impact factor: 3.240
  4 in total

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