| Literature DB >> 1955882 |
T S Wu1, Y M Lin, M Haruna, D J Pan, T Shingu, Y P Chen, H Y Hsu, T Nakano, K H Lee.
Abstract
The extract of the roots of Euphorbia kansui, which has been widely used in Chinese folk medicine for the treatment of cancer, demonstrated antileukemic activity against the P-388 lymphocytic leukemia in mice. Bioassay-directed fractionation of the active extract led to the isolation and characterization of two novel antileukemic diterpene esters, kansuiphorin A [1] [13-hydroxyingenol-3-(2,3-dimethylbutanoate)-13-dodecanoate- 20- hexadecanoate] and kansuiphorin B [2] [6,7-epoxy-13-hydroxyingenol-3-(2,3-dimethylbutanoate)-13-do decanoate-20- hexadecanoate], whose structures were established from spectral evidence and chemical transformation. Kansuiphorins A and B demonstrated potent antileukemic activity with T/C greater than or equal to 176 and 177% at 0.1 and 0.5 mg/kg, respectively. The selectivity of kansuiphorin A, which inhibits the growth of particular cell types within the disease-oriented human cancer cell line panels, is discussed.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1955882 DOI： 10.1021/np50075a011
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050