Literature DB >> 19555123

Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.

Somyote Sutthivaiyakit1, Oracha Thongnak, Thitima Lhinhatrakool, Orapan Yodchun, Ratree Srimark, Prisana Dowtaisong, Mayuree Chuankamnerdkarn.   

Abstract

Eight new prenylated flavonoids, khonklonginols A-H (1-8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1-8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.

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Year:  2009        PMID： 19555123     DOI： 10.1021/np900021h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Neougonin A Inhibits Lipopolysaccharide-Induced Inflammatory Responses via Downregulation of the NF-kB Signaling Pathway in RAW 264.7 Macrophages.

Authors:  Lang Cao; Rongtao Li; Xuanqin Chen; Yong Xue; Dan Liu
Journal:  Inflammation       Date:  2016-12       Impact factor: 4.092

2.  Lupinifolin from Derris reticulata possesses bactericidal activity on Staphylococcus aureus by disrupting bacterial cell membrane.

Authors:  Kamol Yusook; Oratai Weeranantanapan; Yanling Hua; Pakarang Kumkrai; Nuannoi Chudapongse
Journal:  J Nat Med       Date:  2016-12-30       Impact factor: 2.343

3.  1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation.

Authors:  Dongamanti Ashok; Pamula Chiranjeevi; Aamate Vikas Kumar; Madderla Sarasija; Vagolu Siva Krishna; Dharmarajan Sriram; Sridhar Balasubramanian
Journal:  RSC Adv       Date:  2018-05-09       Impact factor: 4.036

4.  Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation.

Authors:  Ashok Dogamanti; Pamula Chiranjeevi; Vikas Kumar Aamate; Siva Krishna Vagolu; Dharmarajan Sriram; Sridhar Balasubramanian; Madderla Sarasija
Journal:  Mol Divers       Date:  2020-05-30       Impact factor: 2.943

Review 5.  Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent.

Authors:  Shuaibu Babaji Sanusi; Mohd Fadzelly Abu Bakar; Maryati Mohamed; Siti Fatimah Sabran; Muhammad Murtala Mainasara
Journal:  Evid Based Complement Alternat Med       Date:  2017-07-03       Impact factor: 2.629

6.  Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda.

Authors:  Benson Oloya; Jane Namukobe; Willy Ssengooba; Mathias Afayoa; Robert Byamukama
Journal:  Trop Med Health       Date:  2022-02-17

Review 7.  Promising Antimycobacterial Activities of Flavonoids against Mycobacterium sp. Drug Targets: A Comprehensive Review.

Authors:  Ali A Rabaan; Saad Alhumaid; Hawra Albayat; Mohammed Alsaeed; Fadwa S Alofi; Mawaheb H Al-Howaidi; Safaa A Turkistani; Salah M Alhajri; Hejji E Alahmed; Abdulwahab B Alzahrani; Mutaib M Mashraqi; Sara Alwarthan; Mashael Alhajri; Fatimah S Alshahrani; Souad A Almuthree; Roua A Alsubki; Abdulmonem A Abuzaid; Mubarak Alfaresi; Mona A Al Fares; Abbas Al Mutair
Journal:  Molecules       Date:  2022-08-22       Impact factor: 4.927

8.  Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice.

Authors:  Mi Huang; Shihao Deng; Qianqian Han; Ping Zhao; Qi Zhou; Sijian Zheng; Xinhua Ma; Chan Xu; Jing Yang; Xinzhou Yang
Journal:  Front Pharmacol       Date:  2016-09-05       Impact factor: 5.810
  8 in total

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