| Literature DB >> 19553114 |
Julie Miyashiro1, Keith W Woods, Chang H Park, Xuesong Liu, Yan Shi, Eric F Johnson, Jennifer J Bouska, Amanda M Olson, Yan Luo, Elizabeth H Fry, Vincent L Giranda, Thomas D Penning.
Abstract
Based on screening hit 1, a series of tricyclic quinoxalinones have been designed and evaluated for inhibition of PARP-1. Substitutions at the 7- and 8-positions of the quinoxalinone ring led to a number of compounds with good enzymatic and cellular potency. The tricyclic quinoxalinone class is sensitive to modifications of both the amine substituent and the tricyclic core. The synthesis and structure-activity relationship studies are presented.Entities:
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Year: 2009 PMID： 19553114 DOI： 10.1016/j.bmcl.2009.06.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823