BACKGROUND: The aim of this study was to determine the accuracy of new quantitative echocardiographic strain and strain-rate imaging parameters to identify abnormal regional right ventricular (RV) deformation associated with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). METHODS: A total of 34 patients with ARVD/C (confirmed by Task Force criteria) and 34 healthy controls were prospectively enrolled. Conventional echocardiography, including Doppler tissue imaging (DTI), was performed. Doppler and two-dimensional strain-derived velocity, strain, and strain rate were calculated in the apical, mid, and basal segments of the RV free wall. RESULTS: RV dimensions were significantly increased in patients with ARVD/C (RV outflow tract 19.3+/-5.2 mm/m2 vs 14.1+/-2.2 mm/m2, P<.001; RV inflow tract 23.4+/-4.8 mm/m2 vs 18.8+/-2.4 mm/m2, P<.001), whereas left ventricular dimensions were not significantly different compared with controls. Strain and strain rate values were significantly lower in patients with ARVD/C in all 3 segments. All deformation parameters showed a higher accuracy to detect functional abnormalities compared with conventional echocardiographic criteria of dimensions or global systolic function. The lowest DTI strain value in any of the 3 analyzed segments showed the best receiver operating characteristics (area under the curve 0.97) with an optimal cutoff value of -18.2%. CONCLUSIONS: DTI and two-dimensional strain-derived parameters are superior to conventional echocardiographic parameters in identifying ARVD/C. This novel technique may have additional value in the diagnostic workup of patients with suspected ARVD/C.
BACKGROUND: The aim of this study was to determine the accuracy of new quantitative echocardiographic strain and strain-rate imaging parameters to identify abnormal regional right ventricular (RV) deformation associated with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). METHODS: A total of 34 patients with ARVD/C (confirmed by Task Force criteria) and 34 healthy controls were prospectively enrolled. Conventional echocardiography, including Doppler tissue imaging (DTI), was performed. Doppler and two-dimensional strain-derived velocity, strain, and strain rate were calculated in the apical, mid, and basal segments of the RV free wall. RESULTS: RV dimensions were significantly increased in patients with ARVD/C (RV outflow tract 19.3+/-5.2 mm/m2 vs 14.1+/-2.2 mm/m2, P<.001; RV inflow tract 23.4+/-4.8 mm/m2 vs 18.8+/-2.4 mm/m2, P<.001), whereas left ventricular dimensions were not significantly different compared with controls. Strain and strain rate values were significantly lower in patients with ARVD/C in all 3 segments. All deformation parameters showed a higher accuracy to detect functional abnormalities compared with conventional echocardiographic criteria of dimensions or global systolic function. The lowest DTI strain value in any of the 3 analyzed segments showed the best receiver operating characteristics (area under the curve 0.97) with an optimal cutoff value of -18.2%. CONCLUSIONS: DTI and two-dimensional strain-derived parameters are superior to conventional echocardiographic parameters in identifying ARVD/C. This novel technique may have additional value in the diagnostic workup of patients with suspected ARVD/C.
Authors: Victor Utomi; David Oxborough; Euan Ashley; Rachel Lord; Sarah Fletcher; Mike Stembridge; Rob Shave; Martin D Hoffman; Greg Whyte; John Somauroo; Sanjay Sharma; Keith George Journal: Eur J Appl Physiol Date: 2015-03-17 Impact factor: 3.078
Authors: Maria Sanz-de la Garza; Geneviève Giraldeau; Josefa Marin; Gonzalo Grazioli; Montserrat Esteve; Luigi Gabrielli; Carlos Brambila; Laura Sanchis; Bart Bijnens; Marta Sitges Journal: Eur J Appl Physiol Date: 2017-02-01 Impact factor: 3.078
Authors: David Oxborough; Annemieke Heemels; John Somauroo; Gavin McClean; Punit Mistry; Rachel Lord; Victor Utomi; Nigel Jones; Dick Thijssen; Sanjay Sharma; Rebecca Osborne; Nicholas Sculthorpe; Keith George Journal: Int J Cardiovasc Imaging Date: 2016-05-21 Impact factor: 2.357
Authors: Mohammad Qasem; Keith George; John Somauroo; Lynsey Forsythe; Benjamin Brown; David Oxborough Journal: Int J Cardiovasc Imaging Date: 2018-02-07 Impact factor: 2.357