| Literature DB >> 19552444 |
Andrew P Townsend1, Stefanie Roth, Huw E L Williams, Eleni Stylianou, Neil R Thomas.
Abstract
Two new and complementary synthetic strategies for 5'-N-chloroethylamino-5'-deoxyadenosines are presented. Additionally, the reaction kinetics of their conversion into aziridines under typical enzyme assay conditions is reported using time-resolved NMR spectroscopy. A stable photocaged derivative of 5'-N-chloroethylamino-5'-deoxyadenosine has also been synthesized, and its stability and activation in aqueous solution at physiological pH have been examined.Entities:
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Year: 2009 PMID： 19552444 DOI： 10.1021/ol9009859
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005