Mark D Thever1, Milton H Saier. 1. Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0116, CA, USA. markthever@gmail.com
Abstract
P-type ATPases play essential roles in numerous processes, which in humans include nerve impulse propagation, relaxation of muscle fibers, secretion and absorption in the kidney, acidification of the stomach and nutrient absorption in the intestine. Published evidence suggests that uncharacterized families of P-type ATPases with novel specificities exist. In this study, the fully sequenced genomes of 26 eukaryotes, including animals, plants, fungi and unicellular eukaryotes, were analyzed for P-type ATPases. We report the organismal distributions, phylogenetic relationships, probable topologies and conserved motifs of nine functionally characterized families and 13 uncharacterized families of these enzyme transporters. We have classified these proteins according to the conventions of the functional and phylogenetic IUBMB-approved transporter classification system ( www.tcdb.org , Saier et al. in Nucleic Acids Res 34:181-186, 2006; Nucleic Acids Res 37:274-278, 2009).
P-type pan class="Gene">ATPases play essential roles in numerous processes, which in humans include nerve impulse propagation, relaxation of muscle fibers, secretion and absorption in the kidney, acidification of the stomach and nutrient absorption in the intestine. Published evidence suggests that uncharacterized families of P-type ATPases with novel specificities exist. In this study, the fully sequenced genomes of 26 eukaryotes, including animals, plants, fungi and unicellular eukaryotes, were analyzed for P-type ATPases. We report the organismal distributions, phylogenetic relationships, probable topologies and conserved motifs of nine functionally characterized families and 13 uncharacterized families of these enzyme transporters. We have classified these proteins according to the conventions of the functional and phylogenetic IUBMB-approved transporter classification system ( www.tcdb.org , Saier et al. in Nucleic Acids Res 34:181-186, 2006; Nucleic Acids Res 37:274-278, 2009).
Authors: Vincent H Lam; Jong-Hoon Lee; Abe Silverio; Henry Chan; Kenny M Gomolplitinant; Tatyana L Povolotsky; Ekaterina Orlova; Eric I Sun; Carl H Welliver; Milton H Saier Journal: Biol Chem Date: 2011-01 Impact factor: 3.915
Authors: Luke C M Mackinder; Chris Chen; Ryan D Leib; Weronika Patena; Sean R Blum; Matthew Rodman; Silvia Ramundo; Christopher M Adams; Martin C Jonikas Journal: Cell Date: 2017-09-21 Impact factor: 41.582
Authors: Mario A Rodríguez; Aarón Martínez-Higuera; Martha I Valle-Solis; Mario Hernandes-Alejandro; Bibiana Chávez-Munguía; Ana H Figueroa-Gutiérrez; Andrés Salas-Casas Journal: Parasitol Res Date: 2018-08-06 Impact factor: 2.289