BACKGROUND: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. METHODS:Clinically depressed outpatients (n=195) were asked about childhood experiences before beginning a randomized antidepressant trial with eitherfluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. RESULTS:Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. CONCLUSIONS: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood. (c) 2009 Wiley-Liss, Inc.
RCT Entities:
BACKGROUND: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. METHODS: Clinically depressed outpatients (n=195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. RESULTS:Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. CONCLUSIONS: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood. (c) 2009 Wiley-Liss, Inc.
Authors: Laura C Bruce; Richard G Heimberg; Carlos Blanco; Franklin R Schneier; Michael R Liebowitz Journal: Depress Anxiety Date: 2011-11-07 Impact factor: 6.505
Authors: Nancy K Grote; Susan J Spieker; Mary Jane Lohr; Sharon L Geibel; Holly A Swartz; Ellen Frank; Patricia R Houck; Wayne Katon Journal: Depress Anxiety Date: 2012-03-23 Impact factor: 6.505
Authors: Chad E Shenk; Brooks Keeshin; Heather E Bensman; Anneke E Olson; Brian Allen Journal: Pharmacol Biochem Behav Date: 2021-11-10 Impact factor: 3.533
Authors: R C Kessler; H M van Loo; K J Wardenaar; R M Bossarte; L A Brenner; D D Ebert; P de Jonge; A A Nierenberg; A J Rosellini; N A Sampson; R A Schoevers; M A Wilcox; A M Zaslavsky Journal: Epidemiol Psychiatr Sci Date: 2016-01-26 Impact factor: 6.892
Authors: Ajeet Bhagat Singh; Chad A Bousman; Chee Hong Ng; Keith Byron; Michael Berk Journal: Clin Psychopharmacol Neurosci Date: 2015-04-30 Impact factor: 2.582