Lawrence P Carter1, Roland R Griffiths, Miriam Z Mintzer. 1. Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street #843, Little Rock, AR 72205, USA.
Abstract
RATIONALE: Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects. OBJECTIVES: This study compared the cognitive effects of GHB (sodium oxybate) with those of triazolam in healthy volunteers. MATERIALS AND METHODS: Doses of sodium oxybate (1.125, 2.25, and 4.5 g/70 kg), triazolam (0.125, 0.25, and 0.5 mg/70 kg), and placebo were administered to 15 volunteers under repeated measures, counterbalanced, double-blind, double-dummy conditions. The time course and peak physiological, psychomotor, subjective, and cognitive effects were examined. RESULTS:Sodium oxybate and triazolam produced similar increases in participant ratings of drug effects. Performance on psychomotor, working memory, and episodic memory tasks was impaired to a greater extent after triazolam than sodium oxybate. CONCLUSIONS: Together, these data suggest that sodium oxybate produces less psychomotor and cognitive impairment than triazolam at doses that produce equivalent participant-rated subjective effects in healthy volunteers.
RCT Entities:
RATIONALE: Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects. OBJECTIVES: This study compared the cognitive effects of GHB (sodium oxybate) with those of triazolam in healthy volunteers. MATERIALS AND METHODS: Doses of sodium oxybate (1.125, 2.25, and 4.5 g/70 kg), triazolam (0.125, 0.25, and 0.5 mg/70 kg), and placebo were administered to 15 volunteers under repeated measures, counterbalanced, double-blind, double-dummy conditions. The time course and peak physiological, psychomotor, subjective, and cognitive effects were examined. RESULTS:Sodium oxybate and triazolam produced similar increases in participant ratings of drug effects. Performance on psychomotor, working memory, and episodic memory tasks was impaired to a greater extent after triazolam than sodium oxybate. CONCLUSIONS: Together, these data suggest that sodium oxybate produces less psychomotor and cognitive impairment than triazolam at doses that produce equivalent participant-rated subjective effects in healthy volunteers.
Authors: Bethea A Kleykamp; Roland R Griffiths; Una D McCann; Michael T Smith; Miriam Z Mintzer Journal: Exp Clin Psychopharmacol Date: 2011-09-19 Impact factor: 3.157
Authors: Amy K Goodwin; Barbara J Kaminski; Roland R Griffiths; Nancy A Ator; Elise M Weerts Journal: Drug Alcohol Depend Date: 2010-11-26 Impact factor: 4.492
Authors: Lawrence P Carter; Bethea A Kleykamp; Roland R Griffiths; Miriam Z Mintzer Journal: Psychopharmacology (Berl) Date: 2012-10-25 Impact factor: 4.530
Authors: Fabio Caputo; Katrin Skala; Antonio Mirijello; Anna Ferrulli; Henriette Walter; Otto Lesch; Giovanni Addolorato Journal: CNS Drugs Date: 2014-08 Impact factor: 5.749
Authors: Lawrence P Carter; Chad J Reissig; Matthew W Johnson; Margaret A Klinedinst; Roland R Griffiths; Miriam Z Mintzer Journal: Drug Alcohol Depend Date: 2012-09-16 Impact factor: 4.492