CONTEXT: Radiotherapy is the cornerstone of treatment in nasopharyngeal cancer (NPC); the addition of chemotherapy has shown improved results. AIMS: To compare the results of concurrent chemoradiation with that of radiotherapy alone in NPC. MATERIALS AND METHODS: One hundred and ninety consecutive NPC patients, without distant metastasis, who reported to the institute from January 1992 to December 2001, received external-beam radiation to 66 Gy in 33 fractions. Seventy-five of these patients received concurrent chemotherapy with cisplatin and 5-fluorouracil (5-FU) for four cycles. We compared the results of treatment in these two groups. RESULTS: The 5-year disease-free survival rates were 40% and 60%, respectively, for patients who had radiotherapy alone and those who had chemoradiation (P = 0.002), while the median survival was 45 months and 60 months, respectively (P = 0.0028). CONCLUSION: A significant improvement in local control and survival was observed by the addition of concurrent chemotherapy with cisplatin and 5-FU to radical radiation in this nonrandomized study on patients with NPC.
CONTEXT: Radiotherapy is the cornerstone of treatment in nasopharyngeal cancer (NPC); the addition of chemotherapy has shown improved results. AIMS: To compare the results of concurrent chemoradiation with that of radiotherapy alone in NPC. MATERIALS AND METHODS: One hundred and ninety consecutive NPCpatients, without distant metastasis, who reported to the institute from January 1992 to December 2001, received external-beam radiation to 66 Gy in 33 fractions. Seventy-five of these patients received concurrent chemotherapy with cisplatin and 5-fluorouracil (5-FU) for four cycles. We compared the results of treatment in these two groups. RESULTS: The 5-year disease-free survival rates were 40% and 60%, respectively, for patients who had radiotherapy alone and those who had chemoradiation (P = 0.002), while the median survival was 45 months and 60 months, respectively (P = 0.0028). CONCLUSION: A significant improvement in local control and survival was observed by the addition of concurrent chemotherapy with cisplatin and 5-FU to radical radiation in this nonrandomized study on patients with NPC.
Authors: T T Terzic; M I Boricic; I P Pendjer; D T Ruzic Zecevic; N R Tomanovic; D C Brasanac; I V Boricic Journal: Med Oncol Date: 2010-05-06 Impact factor: 3.064
Authors: Amel El Korbi; Sarra Ben Tkhayat; Rachida Bouatay; Mehdi Ferjaoui; Naourez Kolsi; Khaled Harrathi; Jamel Koubaa Journal: Pan Afr Med J Date: 2021-02-09