| Literature DB >> 19541619 |
Mickaël V Cherrier1, Victor A Kostyuchenko, Chuan Xiao, Valorie D Bowman, Anthony J Battisti, Xiaodong Yan, Paul R Chipman, Timothy S Baker, James L Van Etten, Michael G Rossmann.
Abstract
Paramecium bursaria Chlorella virus-1 is an icosahedrally shaped, 1,900-A-diameter virus that infects unicellular eukaryotic green algae. A 5-fold symmetric, 3D reconstruction using cryoelectron microscopy images has now shown that the quasiicosahedral virus has a unique vertex, with a pocket on the inside and a spike structure on the outside of the capsid. The pocket might contain enzymes for use in the initial stages of infection. The unique vertex consists of virally coded proteins, some of which have been identified. Comparison of shape, size, and location of the spike with similar features in bacteriophages T4 and P22 suggests that the spike might be a cell-puncturing device. Similar asymmetric features may have been missed in previous analyses of many other viruses that had been assumed to be perfectly icosahedral.Entities:
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Year: 2009 PMID： 19541619 PMCID： PMC2708736 DOI： 10.1073/pnas.0904716106
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205