Literature DB >> 19540628

Aziridine alkaloids as potential therapeutic agents.

Fyaz M D Ismail1, Dmitri O Levitsky, Valery M Dembitsky.   

Abstract

The present review describes research on natural aziridine alkaloids isolated from both terrestrial and marine species, as well as their lipophilic semi-synthetic, and/or synthetic analogs. Over 130 biologically active aziridine-containing compounds demonstrate confirmed pharmacological activity including antitumor, antimicrobial, antibacterial effects. The structures, origin, and biological activities of aziridine alkaloids are reviewed. Consequently this review emphasizes the role of aziridine alkaloids as an important source of drug prototypes and leads for drug discovery.

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Year:  2009        PMID： 19540628     DOI： 10.1016/j.ejmech.2009.05.013

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  24 in total

1.  Multicomponent catalytic asymmetric aziridination of aldehydes.

Authors:  Anil K Gupta; Munmun Mukherjee; William D Wulff
Journal:  Org Lett       Date:  2011-10-11       Impact factor: 6.005

2.  Elucidation of the Reaction Mechanism of C2 + N1 Aziridination from Tetracarbene Iron Catalysts.

Authors:  Sara B Isbill; Preeti P Chandrachud; Jesse L Kern; David M Jenkins; Sharani Roy
Journal:  ACS Catal       Date:  2019-05-31       Impact factor: 13.084

Review 3.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

4.  Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423.

Authors:  Robert T Dorr; Lee Wisner; Betty K Samulitis; Terry H Landowski; William A Remers
Journal:  Cancer Chemother Pharmacol       Date:  2011-12-21       Impact factor: 3.333

5.  Direct stereospecific synthesis of unprotected N-H and N-Me aziridines from olefins.

Authors:  Jawahar L Jat; Mahesh P Paudyal; Hongyin Gao; Qing-Long Xu; Muhammed Yousufuddin; Deepa Devarajan; Daniel H Ess; László Kürti; John R Falck
Journal:  Science       Date:  2014-01-03       Impact factor: 47.728

6.  CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines.

Authors:  Haoxuan Wang; Jeffrey C Yang; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2017-06-15       Impact factor: 15.419

7.  Site-Selective Nitrene Transfer to Conjugated Olefins Directed by Oxazoline Peptide Ligands.

Authors:  Golo Storch; Naudin van den Heuvel; Scott J Miller
Journal:  Adv Synth Catal       Date:  2020-01-23       Impact factor: 5.837

8.  Synthesis of Structurally Diverse 3-, 4-, 5-, and 6-Membered Heterocycles from Diisopropyl Iminomalonates and Soft C-Nucleophiles.

Authors:  Padmanabha V Kattamuri; Urmibhusan Bhakta; Surached Siriwongsup; Doo-Hyun Kwon; Lawrence B Alemany; Muhammed Yousufuddin; Daniel H Ess; László Kürti
Journal:  J Org Chem       Date:  2019-05-14       Impact factor: 4.354

9.  Is the Electrophilicity of the Metal Nitrene the Sole Predictor of Metal-Mediated Nitrene Transfer to Olefins? Secondary Contributing Factors as Revealed by a Library of High-Spin Co(II) Reagents.

Authors:  Anshika Kalra; Vivek Bagchi; Patrina Paraskevopoulou; Purak Das; Lin Ai; Yiannis Sanakis; Grigorios Raptopoulos; Sudip Mohapatra; Amitava Choudhury; Zhicheng Sun; Thomas R Cundari; Pericles Stavropoulos
Journal:  Organometallics       Date:  2021-06-04       Impact factor: 3.876

10.  Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins Using Nonactivated N Atom Precursors.

Authors:  Tianning Deng; Wrickban Mazumdar; Yuki Yoshinaga; Pooja B Patel; Dana Malo; Tala Malo; Donald J Wink; Tom G Driver
Journal:  J Am Chem Soc       Date:  2021-11-08       Impact factor: 15.419
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