| Literature DB >> 19540357 |
Abstract
The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.Entities:
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Year: 2009 PMID： 19540357 PMCID： PMC2731818 DOI： 10.1016/j.bbalip.2009.05.011
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002