RATIONALE AND OBJECTIVES: The purpose of this study was to evaluate prospectively a gadolinium-based perfusion technique for intrarenal blood flow in transplanted kidneys and to determine if magnetic resonance imaging (MRI) measurements of intrarenal perfusion could be used to differentiate between normal-functioning kidney allografts and allografts with acute tubular necrosis (ATN) or acute rejection. MATERIALS AND METHODS: Twenty-one subjects were enrolled within 4 months of receiving a kidney transplant. A biopsy was performed on subjects to diagnose each allograft as having either ATN or acute rejection. A group of subjects with normal functioning transplants was also enrolled in our study. MRI perfusion images were acquired on a 1.5 T MRI system within 48 hours after biopsy using an echo planar, T2*-weighted sequence, and an injection of gadodiamide contrast agent administered at a dose of 0.1 mmol/kg. Scan parameters were: repetition time/echo time/flip = 1000 ms/30 ms/60 degrees , field of view = 340 x 340 mm, matrix = 128 x 64, slice thickness = 10 mm, and temporal resolution = 1.0 seconds. Cortical and medullary blood flow values were calculated. RESULTS: Medullary blood flow values were significantly (P = .02) lower in allografts undergoing acute rejection (121 +/- 41 mL/100 g/min) compared to normal-functioning allografts (221 +/- 96 mL/100 g/min) and those with ATN (247 +/- 124 mL/100 g/min). Cortical blood flow values were also significantly (P = .03) reduced in allografts with acute rejection (243 +/- 116 mL/100 g/min) compared to those with normal function (413 +/- 116 mL/100 g/min). CONCLUSIONS: Preliminary results indicate that MRI perfusion techniques may provide a means of determining noninvasively the viability of renal allografts, potentially alleviating the need for biopsy in some patients.
RATIONALE AND OBJECTIVES: The purpose of this study was to evaluate prospectively a gadolinium-based perfusion technique for intrarenal blood flow in transplanted kidneys and to determine if magnetic resonance imaging (MRI) measurements of intrarenal perfusion could be used to differentiate between normal-functioning kidney allografts and allografts with acute tubular necrosis (ATN) or acute rejection. MATERIALS AND METHODS: Twenty-one subjects were enrolled within 4 months of receiving a kidney transplant. A biopsy was performed on subjects to diagnose each allograft as having either ATN or acute rejection. A group of subjects with normal functioning transplants was also enrolled in our study. MRI perfusion images were acquired on a 1.5 T MRI system within 48 hours after biopsy using an echo planar, T2*-weighted sequence, and an injection of gadodiamide contrast agent administered at a dose of 0.1 mmol/kg. Scan parameters were: repetition time/echo time/flip = 1000 ms/30 ms/60 degrees , field of view = 340 x 340 mm, matrix = 128 x 64, slice thickness = 10 mm, and temporal resolution = 1.0 seconds. Cortical and medullary blood flow values were calculated. RESULTS: Medullary blood flow values were significantly (P = .02) lower in allografts undergoing acute rejection (121 +/- 41 mL/100 g/min) compared to normal-functioning allografts (221 +/- 96 mL/100 g/min) and those with ATN (247 +/- 124 mL/100 g/min). Cortical blood flow values were also significantly (P = .03) reduced in allografts with acute rejection (243 +/- 116 mL/100 g/min) compared to those with normal function (413 +/- 116 mL/100 g/min). CONCLUSIONS: Preliminary results indicate that MRI perfusion techniques may provide a means of determining noninvasively the viability of renal allografts, potentially alleviating the need for biopsy in some patients.
Authors: J F Debatin; R H Ting; H Wegmüller; F G Sommer; J O Fredrickson; T J Brosnan; B S Bowman; B D Myers; R J Herfkens; N J Pelc Journal: Radiology Date: 1994-02 Impact factor: 11.105
Authors: A Helck; M Wessely; M Notohamiprodjo; U Schönermarck; E Klotz; M Fischereder; F Schön; K Nikolaou; D A Clevert; M Reiser; C Becker Journal: Eur Radiol Date: 2013-05-10 Impact factor: 5.315
Authors: Nathan S Artz; Andrew L Wentland; Elizabeth A Sadowski; Arjang Djamali; Thomas M Grist; Songwon Seo; Sean B Fain Journal: Invest Radiol Date: 2011-02 Impact factor: 6.016
Authors: Nathan S Artz; Elizabeth A Sadowski; Andrew L Wentland; Arjang Djamali; Thomas M Grist; Songwon Seo; Sean B Fain Journal: J Magn Reson Imaging Date: 2011-06 Impact factor: 4.813