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Literature DB >> 1953686

Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells.

Abstract

Glucokinase (EC 2.7.1.2) is the signal-recognition enzyme in pancreatic B-cells for initiation of glucose-induced insulin secretion. We show here that both the glucokinase and glucose-transporter GLUT-2 genes are regulated physiologically. Fasting decreased B-cell glucokinase and glucose-transporter GLUT-2 mRNA in pancreatic B-cells as well as in liver, whereas refeeding induced expression of both genes. In pancreatic B-cells a approximately 4.4 kb glucokinase-related mRNA was detectable, in addition to the 2.8 kb form. This approximately 4.4 kb glucokinase transcript was drastically decreased during refeeding. The 2.8 kb mRNA, which is typical for pancreatic B-cells, was accompanied after refeeding by a 2.4 kb mRNA species typical for liver glucokinase. Starvation primarily decreased the 2.8 kb pancreatic B-cell glucokinase mRNA species. The concordant regulation of both genes may represent the basis for the physiological regulation of glucose-induced insulin secretion at a transcriptional level.

Entities: Disease Gene

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Year: 1991 PMID： 1953686 PMCID： PMC1151531 DOI： 10.1042/bj2790899

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

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Journal: Science Date: 1991-03-08 Impact factor: 47.728

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14 in total

Review 1. A fresh view of glycolysis and glucokinase regulation: history and current status.

Authors: Sigurd Lenzen
Journal: J Biol Chem Date: 2014-03-17 Impact factor: 5.157

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Journal: Diabetologia Date: 1993-04 Impact factor: 10.122

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Journal: Biochem J Date: 1993-07-01 Impact factor: 3.857

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Journal: Proc Natl Acad Sci U S A Date: 2000-05-23 Impact factor: 11.205

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Authors: M Tiedge; S Lenzen
Journal: Biochem J Date: 1995-05-15 Impact factor: 3.857

6. Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.

Authors: H Ishihara; T Asano; K Tsukuda; H Katagiri; K Inukai; M Anai; M Kikuchi; Y Yazaki; J I Miyazaki; Y Oka
Journal: Diabetologia Date: 1993-11 Impact factor: 10.122

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Journal: Diabetologia Date: 1992-12 Impact factor: 10.122

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Journal: Biochem J Date: 1993-11-15 Impact factor: 3.857

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Authors: Zhuo Fu; Dongmin Liu
Journal: Eur J Pharmacol Date: 2009-06-18 Impact factor: 4.432

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Authors: C B Chan
Journal: Biochem J Date: 1993-11-01 Impact factor: 3.857