UNLABELLED: Examination of the relationship between early growth and body composition (BC) in infancy might provide clues about the mechanism of early nutrition programming. 150 healthy full-term infants (64 boys) born in Cambridge from 1985-1993 had BC measured using stable isotope at the age of 12 weeks as a part of infant nutrition studies. Fat mass index (FMI, FM/length(2)) and lean mass index (LMI, LM/length(2)) internal standard deviation scores (SDS) were calculated for boys and girls. Birth weight SDS was positively associated with length, BMI and FMI SDS at 12 weeks, but not LMI SDS; equivalent to 0.26 SDS increase in FMI per 1 SDS increase in birth weight (95% CI, 0.04-0.48). Weight SDS change from birth-12 weeks was positively correlated with FMI and LMI SDS at 12 weeks; equivalent to 0.68 SDS and 0.48 SDS increase in FMI and LMI per 1 SDS gain in weight (95% CI, 0.48-0.88 and 0.26-0.70, respectively). Associations were independent of gender, parity, infant diets, and, for weight gain, birth weight SDS. CONCLUSION: Higher birth weight was associated with higher fat mass at 3 months whereas rapid weight gain in the first 3 months was associated with both fat and lean mass. Our data do not support the hypothesis that lean mass tracks directly from fetal life to childhood.
UNLABELLED: Examination of the relationship between early growth and body composition (BC) in infancy might provide clues about the mechanism of early nutrition programming. 150 healthy full-term infants (64 boys) born in Cambridge from 1985-1993 had BC measured using stable isotope at the age of 12 weeks as a part of infant nutrition studies. Fat mass index (FMI, FM/length(2)) and lean mass index (LMI, LM/length(2)) internal standard deviation scores (SDS) were calculated for boys and girls. Birth weight SDS was positively associated with length, BMI and FMI SDS at 12 weeks, but not LMI SDS; equivalent to 0.26 SDS increase in FMI per 1 SDS increase in birth weight (95% CI, 0.04-0.48). Weight SDS change from birth-12 weeks was positively correlated with FMI and LMI SDS at 12 weeks; equivalent to 0.68 SDS and 0.48 SDS increase in FMI and LMI per 1 SDS gain in weight (95% CI, 0.48-0.88 and 0.26-0.70, respectively). Associations were independent of gender, parity, infant diets, and, for weight gain, birth weight SDS. CONCLUSION: Higher birth weight was associated with higher fat mass at 3 months whereas rapid weight gain in the first 3 months was associated with both fat and lean mass. Our data do not support the hypothesis that lean mass tracks directly from fetal life to childhood.
Authors: Katherine A Bell; Carol L Wagner; Henry A Feldman; Roman J Shypailo; Mandy B Belfort Journal: Am J Clin Nutr Date: 2017-06-28 Impact factor: 7.045
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