BACKGROUND: Telomere dysfunction is involved in the development of breast cancer and very short telomeres are frequent genetic alterations in breast tumors. However, the influence of telomere lengths of specific chromosomal arms on the breast cancer risk is unknown. METHODS: We conducted a case-control study of breast cancer to examine the associations of the telomere length on chromosome 9 short arms (9p) and long arms (9q) with risk of breast cancer. Chromosome 9 arm-specific telomere lengths were measured by quantitative fluorescent in situ hybridization using cultured blood lymphocytes. RESULTS:Telomere length on chromosome 9p was significantly shorter in breast cancer patients than in control subjects (P < 0.001). Using the 50th percentile value in controls as a cut point, women who have short 9p telomeres had an increased risk of breast cancer [adjusted odds ratio (OR) = 2.6; 95% confidence interval (CI) = 1.5-4.3]. When the 9p telomere length was divided into quartiles, a significant inverse dose-response relationship between 9p telomere length and breast cancer risk was observed (P(trend) < 0.001), with a quartile ORs of 3.0 (95% CI = 1.2-7.5), 3.9 (95% CI = 1.6-9.5) and 6.6 (95% CI = 2.8-15.9) for third, second and first quartile, respectively, when compared with women in the fourth quartile. CONCLUSIONS: Short telomere length on chromosome 9p is strongly associated with the risk of breast cancer. If confirmed by future studies, chromosome 9p telomere length has the potential to be incorporated into the current prediction models to significantly enhance breast cancer risk prediction.
RCT Entities:
BACKGROUND: Telomere dysfunction is involved in the development of breast cancer and very short telomeres are frequent genetic alterations in breast tumors. However, the influence of telomere lengths of specific chromosomal arms on the breast cancer risk is unknown. METHODS: We conducted a case-control study of breast cancer to examine the associations of the telomere length on chromosome 9 short arms (9p) and long arms (9q) with risk of breast cancer. Chromosome 9 arm-specific telomere lengths were measured by quantitative fluorescent in situ hybridization using cultured blood lymphocytes. RESULTS: Telomere length on chromosome 9p was significantly shorter in breast cancerpatients than in control subjects (P < 0.001). Using the 50th percentile value in controls as a cut point, women who have short 9p telomeres had an increased risk of breast cancer [adjusted odds ratio (OR) = 2.6; 95% confidence interval (CI) = 1.5-4.3]. When the 9p telomere length was divided into quartiles, a significant inverse dose-response relationship between 9p telomere length and breast cancer risk was observed (P(trend) < 0.001), with a quartile ORs of 3.0 (95% CI = 1.2-7.5), 3.9 (95% CI = 1.6-9.5) and 6.6 (95% CI = 2.8-15.9) for third, second and first quartile, respectively, when compared with women in the fourth quartile. CONCLUSIONS: Short telomere length on chromosome 9p is strongly associated with the risk of breast cancer. If confirmed by future studies, chromosome 9p telomere length has the potential to be incorporated into the current prediction models to significantly enhance breast cancer risk prediction.
Authors: Carol Smigal; Ahmedin Jemal; Elizabeth Ward; Vilma Cokkinides; Robert Smith; Holly L Howe; Michael Thun Journal: CA Cancer J Clin Date: 2006 May-Jun Impact factor: 508.702
Authors: Ylva Stewénius; Ludmila Gorunova; Tord Jonson; Nina Larsson; Mattias Höglund; Nils Mandahl; Fredrik Mertens; Felix Mitelman; David Gisselsson Journal: Proc Natl Acad Sci U S A Date: 2005-04-04 Impact factor: 11.205
Authors: So Young Yoon; Hwa Jung Sung; Kyong Hwa Park; In Keun Choi; Seok Jin Kim; Sang Cheul Oh; Jae Hong Seo; Chul Won Choi; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim Journal: Acta Haematol Date: 2007-04-11 Impact factor: 2.195
Authors: Jing Shen; Mary Beth Terry; Irina Gurvich; Yuyan Liao; Ruby T Senie; Regina M Santella Journal: Cancer Res Date: 2007-06-01 Impact factor: 12.701
Authors: Jane Fridlyand; Antoine M Snijders; Bauke Ylstra; Hua Li; Adam Olshen; Richard Segraves; Shanaz Dairkee; Taku Tokuyasu; Britt Marie Ljung; Ajay N Jain; Jane McLennan; John Ziegler; Koei Chin; Sandy Devries; Heidi Feiler; Joe W Gray; Frederic Waldman; Daniel Pinkel; Donna G Albertson Journal: BMC Cancer Date: 2006-04-18 Impact factor: 4.430
Authors: Ourania Kosti; Celia Byrne; Katherine L Meeker; Kenshata M Watkins; Christopher A Loffredo; Peter G Shields; Marc D Schwartz; Shawna C Willey; Costanza Cocilovo; Yun-Ling Zheng Journal: Carcinogenesis Date: 2010-01-28 Impact factor: 4.944
Authors: Ingrid M Wentzensen; Lisa Mirabello; Ruth M Pfeiffer; Sharon A Savage Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-04-05 Impact factor: 4.254
Authors: Abraham Aviv; Steven C Hunt; Jue Lin; Xiaojian Cao; Masayuki Kimura; Elizabeth Blackburn Journal: Nucleic Acids Res Date: 2011-08-08 Impact factor: 16.971
Authors: Clara Bodelon; Christopher M Heaphy; Alan K Meeker; Berta Geller; Pamela M Vacek; Donald L Weaver; Rachael E Chicoine; John A Shepherd; Amir Pasha Mahmoudzadeh; Deesha A Patel; Louise A Brinton; Mark E Sherman; Gretchen L Gierach Journal: BMC Cancer Date: 2015-10-30 Impact factor: 4.430