| Literature DB >> 19535012 |
M R Sulaiman1, E K Perimal, Z A Zakaria, F Mokhtar, M N Akhtar, N H Lajis, D A Israf.
Abstract
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action.Entities:
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Year: 2009 PMID： 19535012 DOI： 10.1016/j.fitote.2009.02.002
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882