PURPOSE: Our purpose was to retrospectively compare controlled ovarian stimulation(COH) in IVF cycles with administration of hCG on the day of menses (D1-hCG) with women not receiving hCG at day 1 of menses (Control). METHODS: Data on maternal age, endocrine profile, amount of rFSH required, embryo characteristics, implantation and pregnancy rates were recorded for comparison between D1-hCG (n = 36) and Control (n = 64). RESULTS: Dose of rFSH required to accomplish COH was significantly lower in D1-hCG. Following ICSI, more top-quality embryos were available for transfer per patient in the D1-hCG and biochemical pregnancy rates per transfer were significantly higher in the D1-hCG. Significantly higher implantation and on-going pregnancy rates per embryo transfer were observed in D1-hCG (64%) compared to Control (41%). CONCLUSIONS: Administration of D1-hCG prior to COH reduces rFSH use and enhances oocyte developmental competence to obtain top quality embryos, and improves implantation and on-going pregnancy rates. At present it is not clear if the benefit is related to producing an embryo that more likely to implant or a more receptive uterus, or merely fortuitous and related to the relatively small power of the study.
PURPOSE: Our purpose was to retrospectively compare controlled ovarian stimulation(COH) in IVF cycles with administration of hCG on the day of menses (D1-hCG) with women not receiving hCG at day 1 of menses (Control). METHODS: Data on maternal age, endocrine profile, amount of rFSH required, embryo characteristics, implantation and pregnancy rates were recorded for comparison between D1-hCG (n = 36) and Control (n = 64). RESULTS: Dose of rFSH required to accomplish COH was significantly lower in D1-hCG. Following ICSI, more top-quality embryos were available for transfer per patient in the D1-hCG and biochemical pregnancy rates per transfer were significantly higher in the D1-hCG. Significantly higher implantation and on-going pregnancy rates per embryo transfer were observed in D1-hCG (64%) compared to Control (41%). CONCLUSIONS: Administration of D1-hCG prior to COH reduces rFSH use and enhances oocyte developmental competence to obtain top quality embryos, and improves implantation and on-going pregnancy rates. At present it is not clear if the benefit is related to producing an embryo that more likely to implant or a more receptive uterus, or merely fortuitous and related to the relatively small power of the study.
Authors: Kazuhiro Kawamura; Nanami Kawamura; Sabine M Mulders; Maarten D Sollewijn Gelpke; Aaron J W Hsueh Journal: Proc Natl Acad Sci U S A Date: 2005-06-20 Impact factor: 11.205
Authors: Marco Filicori; Asgerally T Fazleabas; Ilpo Huhtaniemi; Peter Licht; Ch V Rao; Jan Tesarik; Marek Zygmunt Journal: Fertil Steril Date: 2005-08 Impact factor: 7.329
Authors: M B Zelinski-Wooten; J S Hutchison; I Trinchard-Lugan; D L Hess; D P Wolf; R L Stouffer Journal: Hum Reprod Date: 1997-09 Impact factor: 6.918
Authors: G De Placido; C Alviggi; A Perino; I Strina; F Lisi; A Fasolino; R De Palo; A Ranieri; N Colacurci; A Mollo Journal: Hum Reprod Date: 2004-12-02 Impact factor: 6.918
Authors: M Filicori; C Flamigni; G E Cognigni; A Falbo; R Arnone; M Capelli; A Pavani; M Mandini; P Calderoni; L Brondelli Journal: Fertil Steril Date: 1996-02 Impact factor: 7.329