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Literature DB >> 19530306

Mitochondrial fusion and division: Regulation and role in cell viability.

Abstract

Discovery of various molecular components regulating dynamics and organization of the mitochondria in cells, together with novel insights into the role of mitochondrial fusion and division in the maintenance of cellular homeostasis, have provided some of the most exciting breakthroughs in the last decade of mitochondrial research. The focus of this review is on the regulation of mitochondrial fusion and division machineries. The newly identified factors associated with mitofusin/OPA1-dependent mitochondrial fusion, and Drp1-dependent mitochondrial division are discussed. Furthermore, the most recent findings on the role of mitochondrial fusion and division in the maintenance of cell function are also reviewed here in some detail.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2009 PMID： 19530306 PMCID： PMC2768568 DOI： 10.1016/j.semcdb.2008.12.012

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

103 in total

1. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

Authors: Claudia Zanna; Anna Ghelli; Anna Maria Porcelli; Mariusz Karbowski; Richard J Youle; Simone Schimpf; Bernd Wissinger; Marcello Pinti; Andrea Cossarizza; Sara Vidoni; Maria Lucia Valentino; Michela Rugolo; Valerio Carelli
Journal: Brain Date: 2008-02 Impact factor: 13.501

2. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

Authors: Gilad Twig; Alvaro Elorza; Anthony J A Molina; Hibo Mohamed; Jakob D Wikstrom; Gil Walzer; Linsey Stiles; Sarah E Haigh; Steve Katz; Guy Las; Joseph Alroy; Min Wu; Bénédicte F Py; Junying Yuan; Jude T Deeney; Barbara E Corkey; Orian S Shirihai
Journal: EMBO J Date: 2008-01-17 Impact factor: 11.598

3. Modulation of mitochondrial morphology by bioenergetics defects in primary human fibroblasts.

Authors: O Guillery; F Malka; P Frachon; D Milea; M Rojo; A Lombès
Journal: Neuromuscul Disord Date: 2008-04 Impact factor: 4.296

4. Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.

Authors: Carsten Merkwirth; Sascha Dargazanli; Takashi Tatsuta; Stefan Geimer; Beatrix Löwer; F Thomas Wunderlich; Jürgen-Christoph von Kleist-Retzow; Ari Waisman; Benedikt Westermann; Thomas Langer
Journal: Genes Dev Date: 2008-02-15 Impact factor: 11.361

5. Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.

Authors: Olwenn Guillery; Florence Malka; Thomas Landes; Emmanuelle Guillou; Craig Blackstone; Anne Lombès; Pascale Belenguer; Damien Arnoult; Manuel Rojo
Journal: Biol Cell Date: 2008-05 Impact factor: 4.458

6. SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

Authors: Sandrine Da Cruz; Philippe A Parone; Philippe Gonzalo; Willy V Bienvenut; Daniel Tondera; Alexis Jourdain; Manfredo Quadroni; Jean-Claude Martinou
Journal: Biochim Biophys Acta Date: 2008-02-20

7. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.

Authors: Hongmei Li; Yingbei Chen; Adrienne F Jones; Richard H Sanger; Leon P Collis; Richard Flannery; Ewan C McNay; Tingxi Yu; Robert Schwarzenbacher; Blaise Bossy; Ella Bossy-Wetzel; Michael V L Bennett; Marc Pypaert; John A Hickman; Peter J S Smith; J Marie Hardwick; Elizabeth A Jonas
Journal: Proc Natl Acad Sci U S A Date: 2008-02-04 Impact factor: 11.205

8. OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.

Authors: Patrizia Amati-Bonneau; Maria Lucia Valentino; Pascal Reynier; Maria Esther Gallardo; Belén Bornstein; Anne Boissière; Yolanda Campos; Henry Rivera; Jesús González de la Aleja; Rosanna Carroccia; Luisa Iommarini; Pierre Labauge; Dominique Figarella-Branger; Pascale Marcorelles; Alain Furby; Katell Beauvais; Franck Letournel; Rocco Liguori; Chiara La Morgia; Pasquale Montagna; Maria Liguori; Claudia Zanna; Michela Rugolo; Andrea Cossarizza; Bernd Wissinger; Christophe Verny; Robert Schwarzenbacher; Miguel Angel Martín; Joaquín Arenas; Carmen Ayuso; Rafael Garesse; Guy Lenaers; Dominique Bonneau; Valerio Carelli
Journal: Brain Date: 2007-12-24 Impact factor: 13.501

9. The PINK1/Parkin pathway regulates mitochondrial morphology.

Authors: Angela C Poole; Ruth E Thomas; Laurie A Andrews; Heidi M McBride; Alexander J Whitworth; Leo J Pallanck
Journal: Proc Natl Acad Sci U S A Date: 2008-01-29 Impact factor: 11.205

10. Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.

Authors: Gavin Hudson; Patrizia Amati-Bonneau; Emma L Blakely; Joanna D Stewart; Langping He; Andrew M Schaefer; Philip G Griffiths; Kati Ahlqvist; Anu Suomalainen; Pascal Reynier; Robert McFarland; Douglass M Turnbull; Patrick F Chinnery; Robert W Taylor
Journal: Brain Date: 2007-12-07 Impact factor: 13.501

74 in total

Review 1. Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.

Authors: Theodore J Wilson; Andrew M Slupe; Stefan Strack
Journal: Neurobiol Dis Date: 2012-01-24 Impact factor: 5.996

2. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training.

Authors: Erika Koltai; Nikolett Hart; Albert W Taylor; Sataro Goto; Jenny K Ngo; Kelvin J A Davies; Zsolt Radak
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2012-05-09 Impact factor: 3.619

Mitochondrial fusion and division: Regulation and role in cell viability.

1. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

2. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

3. Modulation of mitochondrial morphology by bioenergetics defects in primary human fibroblasts.

4. Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.

5. Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.

6. SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

7. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.

8. OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.

9. The PINK1/Parkin pathway regulates mitochondrial morphology.

10. Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.

Review 1. Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.

2. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training.

Review 3. Mechanical properties of respiratory muscles.

4. Dynamins at a glance.

5. Discovery of the membrane receptor for mitochondrial fission GTPase Drp1.

6. Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.

Review 7. Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases.

8. Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.

9. Resveratrol enhances exercise training responses in rats selectively bred for high running performance.

10. Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1.