Literature DB >> 1952867

Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures.

D S Lindsay1, B L Blagburn, J E Hall, R R Tidwell.   

Abstract

The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P less than 0.05) reduction in the numbers of tachyzoites produced. Analogs of pentamidine may be useful agents in the treatment of toxoplasmosis.

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Year:  1991        PMID： 1952867      PMCID： PMC245291          DOI： 10.1128/AAC.35.9.1914

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Toxoplasma encephalitis in patients with acquired immune deficiency syndrome: diagnosis and response to therapy.

Authors:  C Wanke; C U Tuazon; A Kovacs; T Dina; D O Davis; N Barton; D Katz; M Lunde; C Levy; F K Conley
Journal:  Am J Trop Med Hyg       Date:  1987-05       Impact factor: 2.345

2.  Treatment of toxoplasmic encephalitis with intravenous clindamycin.

Authors:  B R Dannemann; D M Israelski; J S Remington
Journal:  Arch Intern Med       Date:  1988-11

Review 3.  AIDS commentary. Toxoplasmic encephalitis.

Authors:  B J Luft; J S Remington
Journal:  J Infect Dis       Date:  1988-01       Impact factor: 5.226

4.  Activity of the anticoccidial compound, lasalocid, against Toxoplasma gondii in cultured cells.

Authors:  M L Melton; H G Sheffield
Journal:  J Parasitol       Date:  1975-08       Impact factor: 1.276

5.  Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii.

Authors:  F G Araujo; J Huskinson; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

6.  In vivo and in vitro activity of roxithromycin against Toxoplasma gondii in mice.

Authors:  B J Luft
Journal:  Eur J Clin Microbiol       Date:  1987-08       Impact factor: 3.267

7.  Clindamycin in a murine model of toxoplasmic encephalitis.

Authors:  J M Hofflin; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

8.  Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis.

Authors:  J K Frenkel; A Escajadillo
Journal:  Am J Trop Med Hyg       Date:  1987-05       Impact factor: 2.345

9.  Assessment of therapy for toxoplasma encephalitis. The TE Study Group.

Authors:  H W Haverkos
Journal:  Am J Med       Date:  1987-05       Impact factor: 4.965

10.  In vitro assessment of antimicrobial agents against Toxoplasma gondii.

Authors:  C Harris; M P Salgo; H B Tanowitz; M Wittner
Journal:  J Infect Dis       Date:  1988-01       Impact factor: 5.226
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  7 in total

1.  Evaluation of the efficacy of atovaquone alone or in combination with azithromycin against acute murine toxoplasmosis.

Authors:  S K Moshkani; A Dalimi
Journal:  Vet Res Commun       Date:  2000-04       Impact factor: 2.459

2.  Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia.

Authors:  R R Tidwell; S K Jones; N A Naiman; L C Berger; W B Brake; C C Dykstra; J E Hall
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

3.  Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.

Authors:  J E Hall; J E Kerrigan; K Ramachandran; B C Bender; J P Stanko; S K Jones; D A Patrick; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

4.  Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells.

Authors:  C C Dykstra; D R McClernon; L P Elwell; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

Review 5.  Novel amidines and analogues as promising agents against intracellular parasites: a systematic review.

Authors:  M N C Soeiro; K Werbovetz; D W Boykin; W D Wilson; M Z Wang; A Hemphill
Journal:  Parasitology       Date:  2013-04-08       Impact factor: 3.234

6.  Evaluation of risk and diagnostic value of quantitative assays for anti-Toxoplasma gondii immunoglobulin A (IgA), IgE, and IgM and analytical study of specific IgG in immunodeficient patients.

Authors:  J M Pinon; F Foudrinier; G Mougeot; C Marx; D Aubert; O Toupance; G Niel; M Danis; P Camerlynck; G Remy
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948

7.  Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

Authors:  M Del Poeta; W A Schell; C C Dykstra; S Jones; R R Tidwell; A Czarny; M Bajic; A Kumar; D Boykin; J R Perfect
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
  7 in total

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