Literature DB >> 19524453

The role of CD40 and CD154/CD40L in dendritic cells.

Daphne Y Ma1, Edward A Clark.   

Abstract

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.

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Year:  2009        PMID： 19524453      PMCID： PMC2749083          DOI： 10.1016/j.smim.2009.05.010

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  125 in total

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Journal:  J Immunol       Date:  1996-11-15       Impact factor: 5.422

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Journal:  J Biol Chem       Date:  1996-11-15       Impact factor: 5.157

4.  Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand.

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Journal:  Nature       Date:  1995-12-07       Impact factor: 49.962

5.  CD40 ligand-transduced co-stimulation of T cells in the development of helper function.

Authors:  D van Essen; H Kikutani; D Gray
Journal:  Nature       Date:  1995-12-07       Impact factor: 49.962

6.  Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis.

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Journal:  Science       Date:  1996-09-27       Impact factor: 47.728

7.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Authors:  M Cella; D Scheidegger; K Palmer-Lehmann; P Lane; A Lanzavecchia; G Alber
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

8.  High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Authors:  F Koch; U Stanzl; P Jennewein; K Janke; C Heufler; E Kämpgen; N Romani; G Schuler
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

9.  A novel function of CD40: induction of cell death in transformed cells.

Authors:  S Hess; H Engelmann
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307

10.  CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

Authors:  P Borrow; A Tishon; S Lee; J Xu; I S Grewal; M B Oldstone; R A Flavell
Journal:  J Exp Med       Date:  1996-05-01       Impact factor: 14.307
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  139 in total

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5.  Fas signal promotes the immunosuppressive function of regulatory dendritic cells via the ERK/β-catenin pathway.

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6.  The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responses.

Authors:  Andrea I Loewendorf; Lars Steinbrueck; Christoph Peter; Andreas Busche; Chris A Benedict; Penelope C Kay-Jackson
Journal:  J Virol       Date:  2011-03-16       Impact factor: 5.103

Review 7.  Mechanisms of NK cell activation: CD4(+) T cells enter the scene.

Authors:  Franck Bihl; Claire Germain; Carmelo Luci; Veronique M Braud
Journal:  Cell Mol Life Sci       Date:  2011-08-23       Impact factor: 9.261

8.  IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.

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Journal:  Cell       Date:  2017-06-29       Impact factor: 41.582

Review 9.  Dendritic cells: The warriors upfront-turned defunct in chronic hepatitis C infection.

Authors:  Meenakshi Sachdeva; Yogesh K Chawla; Sunil K Arora
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10.  PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15.

Authors:  Neale T Hanke; Collin J LaCasse; Claire B Larmonier; Darya Alizadeh; Malika Trad; Nona Janikashvili; Bernard Bonnotte; Emmanuel Katsanis; Nicolas Larmonier
Journal:  Eur J Immunol       Date:  2014-05-23       Impact factor: 5.532
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