BACKGROUND & AIMS: There is an extensive yet inconsistent body of literature reporting on the prevalence of adenomatous polyps (adenomas) and colorectal cancer among average risk individuals. The objectives of our study were to determine the pooled prevalence of adenomas and colorectal cancer, as well as nonadvanced and advanced adenomas, among average risk North Americans. METHODS: Articles were obtained by searching electronic databases (MEDLINE: 1950 through March 2008 and EMBASE: 1980 through March 2008), bibliographies, major journals, and conference proceedings, with no language restrictions. Two reviewers independently selected cross-sectional studies reporting adenoma and colorectal cancer prevalence rates in average risk individuals and assessed studies for inclusion and quality, and extracted the data for analysis. Pooled adenoma and colorectal cancer prevalence rates were estimated using fixed and random effects models. Stratification and metaregression was used to assess heterogeneity. RESULTS: Based on 18 included studies, the pooled prevalence of adenomas, colorectal cancer, nonadvanced adenomas, and advanced adenomas was 30.2%, 0.3%, 17.7%, and 5.7%, respectively. Heterogeneity was observed in the pooled prevalence rates for overall adenomas, advanced adenomas, and colorectal cancer and was explained by the mean age (> or = 65 years vs < 65 years) with older cohorts reporting higher prevalence rates. None of the study quality indicators was found to be significant predictors of heterogeneity. CONCLUSIONS: The high prevalence of advanced adenomas and colorectal cancer, especially among older screen-eligible individuals, provides impetus for expanding colorectal cancer screening programs. Furthermore, the pooled prevalence estimates can be used as quality indicators for established programs.
BACKGROUND & AIMS: There is an extensive yet inconsistent body of literature reporting on the prevalence of adenomatous polyps (adenomas) and colorectal cancer among average risk individuals. The objectives of our study were to determine the pooled prevalence of adenomas and colorectal cancer, as well as nonadvanced and advanced adenomas, among average risk North Americans. METHODS: Articles were obtained by searching electronic databases (MEDLINE: 1950 through March 2008 and EMBASE: 1980 through March 2008), bibliographies, major journals, and conference proceedings, with no language restrictions. Two reviewers independently selected cross-sectional studies reporting adenoma and colorectal cancer prevalence rates in average risk individuals and assessed studies for inclusion and quality, and extracted the data for analysis. Pooled adenoma and colorectal cancer prevalence rates were estimated using fixed and random effects models. Stratification and metaregression was used to assess heterogeneity. RESULTS: Based on 18 included studies, the pooled prevalence of adenomas, colorectal cancer, nonadvanced adenomas, and advanced adenomas was 30.2%, 0.3%, 17.7%, and 5.7%, respectively. Heterogeneity was observed in the pooled prevalence rates for overall adenomas, advanced adenomas, and colorectal cancer and was explained by the mean age (> or = 65 years vs < 65 years) with older cohorts reporting higher prevalence rates. None of the study quality indicators was found to be significant predictors of heterogeneity. CONCLUSIONS: The high prevalence of advanced adenomas and colorectal cancer, especially among older screen-eligible individuals, provides impetus for expanding colorectal cancer screening programs. Furthermore, the pooled prevalence estimates can be used as quality indicators for established programs.
Authors: Grace Clarke Hillyer; Benjamin Lebwohl; Richard M Rosenberg; Alfred I Neugut; Randi Wolf; Corey H Basch; Jennie Mata; Edwin Hernandez; Douglas A Corley; Steven Shea; Charles E Basch Journal: Therap Adv Gastroenterol Date: 2014-11 Impact factor: 4.409
Authors: Neal Mehta; Ashraf Abushahin; Meena Sadaps; Mohammad Alomari; John Vargo; Deepa Patil; Rocio Lopez; Matthew Kalady; Conor P Delaney; Emre Gorgun; James Church; Yutaka Saito; Carol A Burke; Amit Bhatt Journal: Surg Endosc Date: 2020-05-29 Impact factor: 4.584
Authors: Ji Yeon Kim; Yoon Suk Jung; Jung Ho Park; Hong Joo Kim; Yong Kyun Cho; Chong Il Sohn; Woo Kyu Jeon; Byung Ik Kim; Kyu Yong Choi; Dong Il Park Journal: World J Gastroenterol Date: 2016-04-07 Impact factor: 5.742
Authors: David A Lieberman; Jennifer L Holub; Cynthia D Morris; Judith Logan; J Lucas Williams; Patricia Carney Journal: Gastroenterology Date: 2014-04-22 Impact factor: 22.682
Authors: Samir Gupta; Han Sun; Sang Yi; Joy Storm; Guanghua Xiao; Bijal A Balasubramanian; Song Zhang; Raheela Ashfaq; Don C Rockey Journal: Cancer Prev Res (Phila) Date: 2014-08-04