BACKGROUND: Although epidemiologic and animal studies suggest a vegetarian diet protects against the development of colorectal cancer, the relationship between vegetarian diet and incidence of colorectal adenoma is not yet conclusive, especially for Asians. AIM: The purpose of this study was to examine the protective effect of a vegetarian diet against colorectal adenoma and advanced adenoma. METHODS: This cross-sectional study compared the prevalence of colorectal adenoma among Buddhist priests, who are obligatory vegetarians, with that among age and sex-matched controls. All the subjects underwent health checkups in a health-promotion center in Korea. RESULT: Colorectal adenoma and advanced adenoma were both more prevalent in the general population group than in the Buddhist priest group (25.2 vs. 17.9 %, 6.7 vs. 2.0 %). However, the prevalence of metabolic syndrome, high body mass index, and waist circumference were higher in the Buddhist priest group. According to univariate analysis, non-vegetarian diet (general population) significantly increased the prevalence of colorectal adenoma and advanced adenoma compared with a vegetarian diet (Buddhist priests) (OR 1.54, 95 % CI 1.08-2.21, P = 0.018; OR 3.60, 95 % CI 1.53-8.48, P = 0.003). In a conditional regression analysis model, non-vegetarian diet was also a significant risk factor for colorectal adenoma and advanced adenoma (OR 1.52, 95 % CI 0.75-2.07, P = 0.043; OR 2.94, CI 0.97-7.18, P = 0.036). CONCLUSIONS: Vegetarianism may be effective in preventing both colorectal adenoma and advanced adenoma in Asians.
BACKGROUND: Although epidemiologic and animal studies suggest a vegetarian diet protects against the development of colorectal cancer, the relationship between vegetarian diet and incidence of colorectal adenoma is not yet conclusive, especially for Asians. AIM: The purpose of this study was to examine the protective effect of a vegetarian diet against colorectal adenoma and advanced adenoma. METHODS: This cross-sectional study compared the prevalence of colorectal adenoma among Buddhist priests, who are obligatory vegetarians, with that among age and sex-matched controls. All the subjects underwent health checkups in a health-promotion center in Korea. RESULT: Colorectal adenoma and advanced adenoma were both more prevalent in the general population group than in the Buddhist priest group (25.2 vs. 17.9 %, 6.7 vs. 2.0 %). However, the prevalence of metabolic syndrome, high body mass index, and waist circumference were higher in the Buddhist priest group. According to univariate analysis, non-vegetarian diet (general population) significantly increased the prevalence of colorectal adenoma and advanced adenoma compared with a vegetarian diet (Buddhist priests) (OR 1.54, 95 % CI 1.08-2.21, P = 0.018; OR 3.60, 95 % CI 1.53-8.48, P = 0.003). In a conditional regression analysis model, non-vegetarian diet was also a significant risk factor for colorectal adenoma and advanced adenoma (OR 1.52, 95 % CI 0.75-2.07, P = 0.043; OR 2.94, CI 0.97-7.18, P = 0.036). CONCLUSIONS: Vegetarianism may be effective in preventing both colorectal adenoma and advanced adenoma in Asians.
Authors: Anita Koushik; David J Hunter; Donna Spiegelman; W Lawrence Beeson; Piet A van den Brandt; Julie E Buring; Eugenia E Calle; Eunyoung Cho; Gary E Fraser; Jo L Freudenheim; Charles S Fuchs; Edward L Giovannucci; R Alexandra Goldbohm; Lisa Harnack; David R Jacobs; Ikuko Kato; Vittorio Krogh; Susanna C Larsson; Michael F Leitzmann; James R Marshall; Marjorie L McCullough; Anthony B Miller; Pirjo Pietinen; Thomas E Rohan; Arthur Schatzkin; Sabina Sieri; Mikko J Virtanen; Alicja Wolk; Anne Zeleniuch-Jacquotte; Shumin M Zhang; Stephanie A Smith-Warner Journal: J Natl Cancer Inst Date: 2007-09-25 Impact factor: 13.506
Authors: D J Harriss; G Atkinson; K George; N Tim Cable; T Reilly; N Haboubi; M Zwahlen; M Egger; A G Renehan Journal: Colorectal Dis Date: 2009-01-17 Impact factor: 3.788
Authors: Jihun Bong; Hyoun Woo Kang; Hyeki Cho; Ji Hyung Nam; Dong Kee Jang; Jae Hak Kim; Jun Kyu Lee; Yun Jeong Lim; Moon-Soo Koh; Jin Ho Lee Journal: Intest Res Date: 2019-11-01