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Literature DB >> 19518277

Nonlinear elasticity of stiff biopolymers connected by flexible linkers.

K E Kasza¹, G H Koenderink, Y C Lin, C P Broedersz, W Messner, F Nakamura, T P Stossel, F C MacKintosh, D A Weitz.

Abstract

Networks of the biopolymer actin, cross-linked by the compliant protein filamin, form soft gels. They can, however, withstand large shear stresses due to their pronounced nonlinear elastic behavior. The nonlinear elasticity can be controlled by varying the number of cross-links per actin filament. We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in quantitative agreement with experiment. This allows us to estimate loads on individual cross-links, which we find to be less than 10 pN.

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Year: 2009 PMID： 19518277 DOI： 10.1103/PhysRevE.79.041928

Source DB: PubMed Journal: Phys Rev E Stat Nonlin Soft Matter Phys ISSN： 1539-3755

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Cited

22 in total

1. Dynamic role of cross-linking proteins in actin rheology.

Authors: Taeyoon Kim; Wonmuk Hwang; Roger D Kamm
Journal: Biophys J Date: 2011-10-05 Impact factor: 4.033

2. Actin filament length tunes elasticity of flexibly cross-linked actin networks.

Authors: K E Kasza; C P Broedersz; G H Koenderink; Y C Lin; W Messner; E A Millman; F Nakamura; T P Stossel; F C Mackintosh; D A Weitz
Journal: Biophys J Date: 2010-08-09 Impact factor: 4.033

3. Cyclic hardening in bundled actin networks.

Authors: K M Schmoller; P Fernández; R C Arevalo; D L Blair; A R Bausch
Journal: Nat Commun Date: 2010 Impact factor: 14.919

4. A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network.

Authors: M Maier; K W Müller; C Heussinger; S Köhler; W A Wall; A R Bausch; O Lieleg
Journal: Eur Phys J E Soft Matter Date: 2015-05-27 Impact factor: 1.890

Nonlinear elasticity of stiff biopolymers connected by flexible linkers.

1. Dynamic role of cross-linking proteins in actin rheology.

2. Actin filament length tunes elasticity of flexibly cross-linked actin networks.

3. Cyclic hardening in bundled actin networks.

4. A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network.

5. Two fundamental mechanisms govern the stiffening of cross-linked networks.

6. A Versatile Framework for Simulating the Dynamic Mechanical Structure of Cytoskeletal Networks.

7. Gelation of semiflexible polyelectrolytes by multivalent counterions.

8. Mechanism of calponin stabilization of cross-linked actin networks.

9. Multiple actin binding domains of Ena/VASP proteins determine actin network stiffening.

10. Stress-enhanced gelation: a dynamic nonlinearity of elasticity.