OBJECTIVES: Phenotype characteristics of inflammatory bowel disease (IBD) may differ significantly among ethnic subpopulations. The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America. METHODS: Using well-characterized phenotype data in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-IBD Genetics Consortium repository on patients with IBD, we compared phenotypic characteristics of 202 French Canadians with those of 1,287 other Caucasian patients. These included diagnosis, anatomical location, disease behavior, extraintestinal manifestations, surgical history, and family history of IBD. RESULTS: French-Canadian patients with Crohn's disease (CD) were less likely to have stricturing disease (11 vs. 21%, P=0.005; odds ratio (OR): 0.45, 95% confidence interval (95% CI): 0.24-0.85). Using a stringent definition of ethnicity (three out of four grandparents being French Canadians, as opposed to self-report, n=148), French Canadians had a tendency toward developing fistulizing CD (37 vs. 28%, P=0.07), and there was an increased prevalence of sacroiliitis among those with IBD (4 vs. 2%, P=0.045). Among French Canadians, the numbers of current smokers in CD (40 vs. 25%, P=0.006) and former smokers in ulcerative colitis (UC) (35 vs. 20%, P=0.03) were significantly higher. The prevalence of one of the three main variants of nucleotide-binding oligomerization domain containing 2 (NOD2) single-nucleotide polymorphisms (SNPs) among French-Canadian CD patients was 43.2%. The 3020insC SNP correlated with small bowel disease in French Canadians (25 [corrected] vs. 0%, P=0.006). CONCLUSIONS: French Canadians show an IBD phenotype profile distinct from other Caucasian IBD populations, with an accentuated association between smoking status and IBD. This unique profile may have implications regarding the need for a different approach to the management of IBD in this population.
OBJECTIVES: Phenotype characteristics of inflammatory bowel disease (IBD) may differ significantly among ethnic subpopulations. The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America. METHODS: Using well-characterized phenotype data in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-IBD Genetics Consortium repository on patients with IBD, we compared phenotypic characteristics of 202 French Canadians with those of 1,287 other Caucasian patients. These included diagnosis, anatomical location, disease behavior, extraintestinal manifestations, surgical history, and family history of IBD. RESULTS: French-Canadian patients with Crohn's disease (CD) were less likely to have stricturing disease (11 vs. 21%, P=0.005; odds ratio (OR): 0.45, 95% confidence interval (95% CI): 0.24-0.85). Using a stringent definition of ethnicity (three out of four grandparents being French Canadians, as opposed to self-report, n=148), French Canadians had a tendency toward developing fistulizing CD (37 vs. 28%, P=0.07), and there was an increased prevalence of sacroiliitis among those with IBD (4 vs. 2%, P=0.045). Among French Canadians, the numbers of current smokers in CD (40 vs. 25%, P=0.006) and former smokers in ulcerative colitis (UC) (35 vs. 20%, P=0.03) were significantly higher. The prevalence of one of the three main variants of nucleotide-binding oligomerization domain containing 2 (NOD2) single-nucleotide polymorphisms (SNPs) among French-Canadian CD patients was 43.2%. The 3020insC SNP correlated with small bowel disease in French Canadians (25 [corrected] vs. 0%, P=0.006). CONCLUSIONS: French Canadians show an IBD phenotype profile distinct from other Caucasian IBD populations, with an accentuated association between smoking status and IBD. This unique profile may have implications regarding the need for a different approach to the management of IBD in this population.
Authors: C Gasche; J Scholmerich; J Brynskov; G D'Haens; S B Hanauer; E J Irvine; D P Jewell; D Rachmilewitz; D B Sachar; W J Sandborn; L R Sutherland Journal: Inflamm Bowel Dis Date: 2000-02 Impact factor: 5.325
Authors: Themistocles Dassopoulos; Geoffrey C Nguyen; Alain Bitton; Gillian P Bromfield; L Philip Schumm; Yahong Wu; Abdul Elkadri; Miguel Regueiro; Benjamin Siemanowski; Esther A Torres; Federico J Gregory; Sunanda V Kane; Laura E Harrell; Denis Franchimont; Jean-Paul Achkar; Anne Griffiths; Steven R Brant; John D Rioux; Kent D Taylor; Richard H Duerr; Mark S Silverberg; Judy H Cho; A Hillary Steinhart Journal: Inflamm Bowel Dis Date: 2007-08 Impact factor: 5.325
Authors: Jeffrey C Barrett; Sarah Hansoul; Dan L Nicolae; Judy H Cho; Richard H Duerr; John D Rioux; Steven R Brant; Mark S Silverberg; Kent D Taylor; M Michael Barmada; Alain Bitton; Themistocles Dassopoulos; Lisa Wu Datta; Todd Green; Anne M Griffiths; Emily O Kistner; Michael T Murtha; Miguel D Regueiro; Jerome I Rotter; L Philip Schumm; A Hillary Steinhart; Stephan R Targan; Ramnik J Xavier; Cécile Libioulle; Cynthia Sandor; Mark Lathrop; Jacques Belaiche; Olivier Dewit; Ivo Gut; Simon Heath; Debby Laukens; Myriam Mni; Paul Rutgeerts; André Van Gossum; Diana Zelenika; Denis Franchimont; Jean-Pierre Hugot; Martine de Vos; Severine Vermeire; Edouard Louis; Lon R Cardon; Carl A Anderson; Hazel Drummond; Elaine Nimmo; Tariq Ahmad; Natalie J Prescott; Clive M Onnie; Sheila A Fisher; Jonathan Marchini; Jilur Ghori; Suzannah Bumpstead; Rhian Gwilliam; Mark Tremelling; Panos Deloukas; John Mansfield; Derek Jewell; Jack Satsangi; Christopher G Mathew; Miles Parkes; Michel Georges; Mark J Daly Journal: Nat Genet Date: 2008-06-29 Impact factor: 38.330
Authors: John V Raelson; Randall D Little; Andreas Ruether; Hélène Fournier; Bruno Paquin; Paul Van Eerdewegh; W E C Bradley; Pascal Croteau; Quynh Nguyen-Huu; Jonathan Segal; Sophie Debrus; René Allard; Philip Rosenstiel; Andre Franke; Gunnar Jacobs; Susanna Nikolaus; Jean-Michel Vidal; Peter Szego; Nathalie Laplante; Hilary F Clark; René J Paulussen; John W Hooper; Tim P Keith; Abdelmajid Belouchi; Stefan Schreiber Journal: Proc Natl Acad Sci U S A Date: 2007-09-05 Impact factor: 11.205
Authors: Tariq Ahmad; Alessandro Armuzzi; Mike Bunce; Kim Mulcahy-Hawes; Sara E Marshall; Timothy R Orchard; Jonathan Crawshaw; Oliver Large; Arjuna de Silva; Julia T Cook; Martin Barnardo; Sue Cullen; Ken I Welsh; Derek P Jewell Journal: Gastroenterology Date: 2002-04 Impact factor: 22.682
Authors: Mark M Sasaki; Andrew D Skol; Riyue Bao; Lindsay V Rhodes; Rachelle Chambers; Everett E Vokes; Ezra E W Cohen; Kenan Onel Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-05-26 Impact factor: 4.254
Authors: Elizabeth Harrison; Philip Allan; Amrutha Ramu; Anil Vaidya; Simon Travis; Simon Lal Journal: World J Gastroenterol Date: 2014-03-28 Impact factor: 5.742
Authors: Eric I Benchimol; Charles N Bernstein; Alain Bitton; Matthew W Carroll; Harminder Singh; Anthony R Otley; Maria Vutcovici; Wael El-Matary; Geoffrey C Nguyen; Anne M Griffiths; David R Mack; Kevan Jacobson; Nassim Mojaverian; Divine Tanyingoh; Yunsong Cui; Zoann J Nugent; Janie Coulombe; Laura E Targownik; Jennifer L Jones; Desmond Leddin; Sanjay K Murthy; Gilaad G Kaplan Journal: Am J Gastroenterol Date: 2017-04-18 Impact factor: 10.864