BACKGROUND: Patient-reported outcomes like health-related quality of life (HRQL) have become increasingly important for full assessment of patients with chronic liver diseases (CLD). AIM: To explore the relative impact of different types of liver disease on HRQL as well as predictors of HRQL domains in CLD. METHODS: Our HRQL databases with Short-Form 36 (SF-36) data were used. Scores for each of SF-36 scales (PF - physical functioning, RP - role functioning, BP - bodily pain, GH - general health, VT - vitality, SF - social functioning, RE - role emotional and MH - mental health, MCS - mental component score, PCS - physical component score) were compared between different types of CLD as well as other variables. RESULTS: Complete data were available for 1103 CLD patients. Demographic and clinical data included: age 54.2 +/- 12.0 years, 40% female, 761 (69%) with cirrhosis. Analysis revealed that age correlated significantly (P < 0.05) with worsening HRQL on every scale of the SF-36. Female patients had more HRQL impairments in PF, RP, BP, GH, VT and MH scales of SF-36 (Delta scale score: 6.6-10.7, P < 0.05). Furthermore, cirrhotic patients had more impairment of HRQL in every scale of SF-36 (Delta scale score: 6.6-43.0, P < 0.05). In terms of diagnostic groups, non-alcoholic fatty liver disease patients showed more impairment of HRQL. CONCLUSIONS: Analysis of this large CLD cohort suggests that a number of important clinicodemographic factors are associated with HRQL impairment. These findings contribute to the full understanding of the total impact of CLD on patients' health.
BACKGROUND:Patient-reported outcomes like health-related quality of life (HRQL) have become increasingly important for full assessment of patients with chronic liver diseases (CLD). AIM: To explore the relative impact of different types of liver disease on HRQL as well as predictors of HRQL domains in CLD. METHODS: Our HRQL databases with Short-Form 36 (SF-36) data were used. Scores for each of SF-36 scales (PF - physical functioning, RP - role functioning, BP - bodily pain, GH - general health, VT - vitality, SF - social functioning, RE - role emotional and MH - mental health, MCS - mental component score, PCS - physical component score) were compared between different types of CLD as well as other variables. RESULTS: Complete data were available for 1103 CLD patients. Demographic and clinical data included: age 54.2 +/- 12.0 years, 40% female, 761 (69%) with cirrhosis. Analysis revealed that age correlated significantly (P < 0.05) with worsening HRQL on every scale of the SF-36. Female patients had more HRQL impairments in PF, RP, BP, GH, VT and MH scales of SF-36 (Delta scale score: 6.6-10.7, P < 0.05). Furthermore, cirrhotic patients had more impairment of HRQL in every scale of SF-36 (Delta scale score: 6.6-43.0, P < 0.05). In terms of diagnostic groups, non-alcoholic fatty liver diseasepatients showed more impairment of HRQL. CONCLUSIONS: Analysis of this large CLD cohort suggests that a number of important clinicodemographic factors are associated with HRQL impairment. These findings contribute to the full understanding of the total impact of CLD on patients' health.
Authors: Maria Stepanova; Fatema Nader; Christophe Bureau; Danielle Adebayo; Laure Elkrief; Dominique Valla; Markus Peck-Radosavljevic; Anne McCune; Victor Vargas; Macarena Simon-Talero; Juan Cordoba; Paolo Angeli; Silvia Rossi; Stewart MacDonald; Jeroen Capel; Rajiv Jalan; Zobair M Younossi Journal: Qual Life Res Date: 2018-02-19 Impact factor: 4.147
Authors: Vincenzo O Palmieri; Daniela Santovito; Francesco Margari; Madia Lozupone; Francesco Minerva; Carla Di Gennaro; Orlando Todarello; Giuseppe Palasciano Journal: Clin Exp Med Date: 2013-12-10 Impact factor: 3.984
Authors: D P Graham; L Savas; D White; R El-Serag; S Laday-Smith; G Tan; H B El-Serag Journal: Aliment Pharmacol Ther Date: 2009-10-08 Impact factor: 8.171